Interleukin 33

Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. IL-33 is a member of the interleukin family of cytokines that are involved in the immune response.

Function

IL-33 is a cytokine that binds to the ST2 receptor (a member of the Toll-like receptor superfamily) and is known to drive production of other cytokines (such as IL-4, IL-5, and IL-13) that induce T-helper cell type 2 (Th2) responses. It is expressed by various cell types, including fibroblasts, mast cells, and dendritic cells, and can be released upon cell death.

Clinical significance

IL-33 has been implicated in a variety of diseases, including asthma, rheumatoid arthritis, and cardiovascular disease. It is thought to play a role in the pathogenesis of these diseases by promoting inflammation and tissue damage.

See also

• Interleukin
• Cytokine
• Immune response

References

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External links

• IL33 gene at NCBI
• IL-33 protein at UniProt

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