Nuclear receptor co-repressor 2: Difference between revisions

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'''Nuclear receptor co-repressor 2'''


[[File:Nuclear receptor co-repressor 2.jpg|thumb|right|300px|Nuclear receptor co-repressor 2]]
{{Infobox protein
| name = Nuclear receptor co-repressor 2
| image = <!-- Image removed -->
| caption = <!-- Caption removed -->
| symbol = NCOR2
| HGNCid = 7671
| OMIM = 600849
| PDB = 1XU7
| RefSeq = NM_006312
| UniProt = Q9Y618
}}


The '''Nuclear receptor co-repressor 2''' (NCOR2), also known as '''Silencing Mediator for Retinoid or Thyroid-hormone receptors''' (SMRT), is a protein that in humans is encoded by the ''NCOR2'' gene. This protein is part of the larger nuclear receptor co-repressors family, which plays a crucial role in gene expression regulation.
'''Nuclear receptor co-repressor 2''' ('''NCOR2'''), also known as '''silencing mediator for retinoid or thyroid-hormone receptors''' ('''SMRT'''), is a [[protein]] that in humans is encoded by the '''NCOR2''' [[gene]].


== Function ==
== Function ==
NCOR2 is a transcriptional [[corepressor]] that mediates the transcriptional repression of [[nuclear receptors]] in the absence of [[ligand]]. It is involved in the regulation of [[gene expression]] by interacting with [[histone deacetylases]] (HDACs) and other components of the [[chromatin]] remodeling complex. This interaction is crucial for the repression of [[target genes]] by nuclear receptors such as the [[thyroid hormone receptor]] and the [[retinoic acid receptor]].


NCOR2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. It is known to play an essential role in the regulation of cellular growth and differentiation, and it is involved in the regulation of circadian rhythms. The protein functions as a part of a complex along with histone deacetylases and other co-repressors to control the transcriptional activity of certain nuclear receptors.
== Interactions ==
NCOR2 has been shown to interact with several proteins, including:
* [[Histone deacetylase 3]] (HDAC3)
* [[Retinoic acid receptor alpha]] (RARA)
* [[Thyroid hormone receptor beta]] (THRB)
* [[Peroxisome proliferator-activated receptor gamma]] (PPARG)


== Structure ==
These interactions are essential for the recruitment of NCOR2 to the promoter regions of target genes, where it exerts its repressive effects.


The NCOR2 protein is composed of several domains, including two repression domains (RD), two receptor interaction domains (RID), and a C-terminal domain. The RDs are responsible for the interaction with histone deacetylases, while the RIDs interact with nuclear receptors. The C-terminal domain is involved in protein-protein interactions.
== Clinical significance ==
Mutations or dysregulation of NCOR2 have been implicated in various [[diseases]], including certain types of [[cancer]] and [[metabolic disorders]]. The role of NCOR2 in [[cancer]] is particularly significant, as it can influence the expression of genes involved in [[cell proliferation]] and [[apoptosis]].


== Clinical Significance ==
== See also ==
 
* [[Nuclear receptor co-repressor 1]] (NCOR1)
Mutations in the ''NCOR2'' gene have been associated with several types of cancer, including breast cancer and prostate cancer. The protein's role in gene regulation makes it a potential target for therapeutic interventions.
* [[Transcriptional coregulator]]
 
* [[Chromatin remodeling]]
== See Also ==
 
* [[Nuclear receptor]]
* [[Co-repressor]]
* [[Gene expression]]
* [[Histone deacetylase]]


== References ==
== References ==
<references />


<references />
== External links ==
* {{GeneReviews|NCOR2}}
* {{OMIM|600849}}


[[Category:Proteins]]
[[Category:Human proteins]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Nuclear receptors]]
[[Category:Chromatin remodeling]]
[[Category:Co-repressors]]

Latest revision as of 16:50, 29 December 2024


Nuclear receptor co-repressor 2 (NCOR2), also known as silencing mediator for retinoid or thyroid-hormone receptors (SMRT), is a protein that in humans is encoded by the NCOR2 gene.

Function[edit]

NCOR2 is a transcriptional corepressor that mediates the transcriptional repression of nuclear receptors in the absence of ligand. It is involved in the regulation of gene expression by interacting with histone deacetylases (HDACs) and other components of the chromatin remodeling complex. This interaction is crucial for the repression of target genes by nuclear receptors such as the thyroid hormone receptor and the retinoic acid receptor.

Interactions[edit]

NCOR2 has been shown to interact with several proteins, including:

These interactions are essential for the recruitment of NCOR2 to the promoter regions of target genes, where it exerts its repressive effects.

Clinical significance[edit]

Mutations or dysregulation of NCOR2 have been implicated in various diseases, including certain types of cancer and metabolic disorders. The role of NCOR2 in cancer is particularly significant, as it can influence the expression of genes involved in cell proliferation and apoptosis.

See also[edit]

References[edit]

<references />

External links[edit]

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