Haemophilia A: Difference between revisions
From WikiMD's Wellness Encyclopedia
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
'''Haemophilia A''' is a genetic disorder that affects the body's ability to clot blood. It is caused by a deficiency in factor VIII, a protein that is necessary for blood clotting. This condition is typically inherited and affects males more often than females. | {{SI}} | ||
{{Infobox medical condition | |||
| name = Haemophilia A | |||
| image = [[File:Protein_F8_PDB_1d7p.png|250px]] | |||
| caption = Structure of factor VIII | |||
| synonyms = Classical haemophilia, factor VIII deficiency | |||
| pronounce = | |||
| specialty = [[Hematology]] | |||
| symptoms = [[Prolonged bleeding]], [[easy bruising]], [[joint pain]] | |||
| complications = [[Hemarthrosis]], [[intracranial hemorrhage]], [[anemia]] | |||
| onset = [[Childhood]] | |||
| duration = [[Lifelong]] | |||
| types = | |||
| causes = [[Genetic mutation]] in the [[F8 gene]] | |||
| risks = [[Family history]] | |||
| diagnosis = [[Blood test]] for [[factor VIII]] activity | |||
| differential = [[Von Willebrand disease]], [[Hemophilia B]] | |||
| prevention = | |||
| treatment = [[Factor VIII replacement therapy]], [[desmopressin]] | |||
| medication = | |||
| prognosis = [[Variable]], depends on severity and treatment | |||
| frequency = 1 in 5,000 male births | |||
| deaths = | |||
}} | |||
[[File:Gray299.png|thumb|Haemophilia A]] | |||
[[File:X recessive carrier mother.svg|thumb|Haemophilia A]] | |||
[[File:Medical X-Ray imaging JDH05 nevit.jpg|left|thumb|Haemophilia A]] | |||
[[File:Medical X-Ray imaging JDG05 nevit.jpg|left|thumb|Haemophilia A]] | |||
[[File:Desmopressin ball-and-stick.png|thumb|Haemophilia A]] | |||
[[File:Faktor-VIII.jpg|left|thumb|Haemophilia A]] | |||
'''Haemophilia A''' is a genetic disorder that affects the body's ability to clot blood. It is caused by a deficiency in factor VIII, a protein that is necessary for blood clotting. This condition is typically inherited and affects males more often than females. | |||
== Symptoms == | == Symptoms == | ||
The primary symptom of Haemophilia A is prolonged bleeding. This can occur after an injury or surgery, and in severe cases, spontaneous bleeding can occur. Other symptoms can include: | The primary symptom of Haemophilia A is prolonged bleeding. This can occur after an injury or surgery, and in severe cases, spontaneous bleeding can occur. Other symptoms can include: | ||
* [[Bleeding into joints]] and muscles | * [[Bleeding into joints]] and muscles | ||
* [[Blood in urine]] or stool | * [[Blood in urine]] or stool | ||
| Line 10: | Line 37: | ||
* [[Bruising]] | * [[Bruising]] | ||
* [[Bleeding gums]] | * [[Bleeding gums]] | ||
== Causes == | == Causes == | ||
Haemophilia A is caused by a mutation in the F8 gene, which provides instructions for making factor VIII. This mutation can be inherited from a parent, or it can occur spontaneously. | Haemophilia A is caused by a mutation in the F8 gene, which provides instructions for making factor VIII. This mutation can be inherited from a parent, or it can occur spontaneously. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of Haemophilia A typically involves blood tests to measure the level of factor VIII in the blood. Genetic testing may also be used to identify the specific mutation causing the condition. | Diagnosis of Haemophilia A typically involves blood tests to measure the level of factor VIII in the blood. Genetic testing may also be used to identify the specific mutation causing the condition. | ||
== Treatment == | == Treatment == | ||
Treatment for Haemophilia A typically involves replacing the missing factor VIII through infusions. Other treatments can include: | Treatment for Haemophilia A typically involves replacing the missing factor VIII through infusions. Other treatments can include: | ||
* [[Antifibrinolytic medicines]] | * [[Antifibrinolytic medicines]] | ||
* [[Physical therapy]] | * [[Physical therapy]] | ||
* [[Pain medicines]] | * [[Pain medicines]] | ||
== See Also == | == See Also == | ||
* [[Haemophilia B]] | * [[Haemophilia B]] | ||
* [[Von Willebrand disease]] | * [[Von Willebrand disease]] | ||
* [[Factor V Leiden]] | * [[Factor V Leiden]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category:Haemophilia]] | [[Category:Haemophilia]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 04:26, 14 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Haemophilia A | |
|---|---|
| |
| Synonyms | Classical haemophilia, factor VIII deficiency |
| Pronounce | |
| Specialty | Hematology |
| Symptoms | Prolonged bleeding, easy bruising, joint pain |
| Complications | Hemarthrosis, intracranial hemorrhage, anemia |
| Onset | Childhood |
| Duration | Lifelong |
| Types | |
| Causes | Genetic mutation in the F8 gene |
| Risks | Family history |
| Diagnosis | Blood test for factor VIII activity |
| Differential diagnosis | Von Willebrand disease, Hemophilia B |
| Prevention | |
| Treatment | Factor VIII replacement therapy, desmopressin |
| Medication | |
| Prognosis | Variable, depends on severity and treatment |
| Frequency | 1 in 5,000 male births |
| Deaths | |
Haemophilia A is a genetic disorder that affects the body's ability to clot blood. It is caused by a deficiency in factor VIII, a protein that is necessary for blood clotting. This condition is typically inherited and affects males more often than females.
Symptoms[edit]
The primary symptom of Haemophilia A is prolonged bleeding. This can occur after an injury or surgery, and in severe cases, spontaneous bleeding can occur. Other symptoms can include:
- Bleeding into joints and muscles
- Blood in urine or stool
- Nosebleeds
- Bruising
- Bleeding gums
Causes[edit]
Haemophilia A is caused by a mutation in the F8 gene, which provides instructions for making factor VIII. This mutation can be inherited from a parent, or it can occur spontaneously.
Diagnosis[edit]
Diagnosis of Haemophilia A typically involves blood tests to measure the level of factor VIII in the blood. Genetic testing may also be used to identify the specific mutation causing the condition.
Treatment[edit]
Treatment for Haemophilia A typically involves replacing the missing factor VIII through infusions. Other treatments can include:
See Also[edit]
References[edit]
<references />
