Malignant chondroid syringoma: Difference between revisions
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{{Infobox medical condition | |||
| name = Malignant chondroid syringoma | |||
| image = [[File:Malignant_Chondroid_Syringoma.jpg|250px]] | |||
| caption = Histopathological image of malignant chondroid syringoma | |||
| field = [[Dermatology]], [[Oncology]] | |||
| synonyms = Malignant mixed tumor of the skin | |||
| symptoms = Painless, slow-growing mass, often on the head or neck | |||
| complications = Local recurrence, metastasis | |||
| onset = Typically in adults | |||
| duration = Chronic | |||
| causes = Unknown | |||
| risks = Previous benign chondroid syringoma, age | |||
| diagnosis = [[Biopsy]], [[Histopathology]] | |||
| differential = [[Benign chondroid syringoma]], [[Basal cell carcinoma]], [[Squamous cell carcinoma]] | |||
| treatment = [[Surgical excision]], [[Radiation therapy]] | |||
| medication = None specific | |||
| prognosis = Variable, depends on stage and treatment | |||
| frequency = Rare | |||
}} | |||
[[File:34_year_old_woman_with_malignant_chondroid_syringoma.jpg|34-year-old woman with malignant chondroid syringoma|thumb|left]] | |||
'''Malignant chondroid syringoma''' (MCS), also known as '''malignant mixed tumor of the skin''', is a rare type of [[cancer]] that primarily affects the skin. It is a malignant variant of [[chondroid syringoma]], which is a benign tumor that originates from the sweat glands. | '''Malignant chondroid syringoma''' (MCS), also known as '''malignant mixed tumor of the skin''', is a rare type of [[cancer]] that primarily affects the skin. It is a malignant variant of [[chondroid syringoma]], which is a benign tumor that originates from the sweat glands. | ||
==Epidemiology== | ==Epidemiology== | ||
Malignant chondroid syringoma is extremely rare, with fewer than 50 cases reported in the literature. It can occur at any age, but is most commonly diagnosed in adults between the ages of 30 and 60. There is no known gender or racial predilection. | Malignant chondroid syringoma is extremely rare, with fewer than 50 cases reported in the literature. It can occur at any age, but is most commonly diagnosed in adults between the ages of 30 and 60. There is no known gender or racial predilection. | ||
==Pathogenesis== | ==Pathogenesis== | ||
The exact cause of malignant chondroid syringoma is unknown. It is believed to arise from the [[eccrine sweat glands]], which are a type of sweat gland found throughout the body. The tumor is composed of both epithelial and mesenchymal components, reflecting its mixed origin. | The exact cause of malignant chondroid syringoma is unknown. It is believed to arise from the [[eccrine sweat glands]], which are a type of sweat gland found throughout the body. The tumor is composed of both epithelial and mesenchymal components, reflecting its mixed origin. | ||
==Clinical Features== | ==Clinical Features== | ||
Patients with malignant chondroid syringoma typically present with a slow-growing, painless nodule on the skin. The most common locations are the head and neck, but the tumor can occur anywhere on the body. Other symptoms may include ulceration of the skin and regional [[lymphadenopathy]]. | Patients with malignant chondroid syringoma typically present with a slow-growing, painless nodule on the skin. The most common locations are the head and neck, but the tumor can occur anywhere on the body. Other symptoms may include ulceration of the skin and regional [[lymphadenopathy]]. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of malignant chondroid syringoma is made based on the clinical presentation and histopathological examination of the tumor. [[Immunohistochemistry]] may be used to confirm the diagnosis. The tumor cells typically express markers of both epithelial and mesenchymal differentiation. | The diagnosis of malignant chondroid syringoma is made based on the clinical presentation and histopathological examination of the tumor. [[Immunohistochemistry]] may be used to confirm the diagnosis. The tumor cells typically express markers of both epithelial and mesenchymal differentiation. | ||
==Treatment== | ==Treatment== | ||
The mainstay of treatment for malignant chondroid syringoma is surgical excision of the tumor. [[Radiation therapy]] and [[chemotherapy]] may be used in cases where the tumor is not completely resectable or has metastasized to other parts of the body. | The mainstay of treatment for malignant chondroid syringoma is surgical excision of the tumor. [[Radiation therapy]] and [[chemotherapy]] may be used in cases where the tumor is not completely resectable or has metastasized to other parts of the body. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of malignant chondroid syringoma is generally poor due to its aggressive nature and tendency to recur and metastasize. The 5-year survival rate is estimated to be less than 50%. | The prognosis of malignant chondroid syringoma is generally poor due to its aggressive nature and tendency to recur and metastasize. The 5-year survival rate is estimated to be less than 50%. | ||
==See Also== | ==See Also== | ||
* [[Chondroid syringoma]] | * [[Chondroid syringoma]] | ||
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* [[Cancer]] | * [[Cancer]] | ||
* [[Immunohistochemistry]] | * [[Immunohistochemistry]] | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
[[Category:Cancers]] | [[Category:Cancers]] | ||
| Line 30: | Line 43: | ||
{{Skin-disease-stub}} | {{Skin-disease-stub}} | ||
{{Cancer-stub}} | {{Cancer-stub}} | ||
Latest revision as of 05:35, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
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| Malignant chondroid syringoma | |
|---|---|
| |
| Synonyms | Malignant mixed tumor of the skin |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Painless, slow-growing mass, often on the head or neck |
| Complications | Local recurrence, metastasis |
| Onset | Typically in adults |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown |
| Risks | Previous benign chondroid syringoma, age |
| Diagnosis | Biopsy, Histopathology |
| Differential diagnosis | Benign chondroid syringoma, Basal cell carcinoma, Squamous cell carcinoma |
| Prevention | N/A |
| Treatment | Surgical excision, Radiation therapy |
| Medication | None specific |
| Prognosis | Variable, depends on stage and treatment |
| Frequency | Rare |
| Deaths | N/A |
Malignant chondroid syringoma (MCS), also known as malignant mixed tumor of the skin, is a rare type of cancer that primarily affects the skin. It is a malignant variant of chondroid syringoma, which is a benign tumor that originates from the sweat glands.
Epidemiology[edit]
Malignant chondroid syringoma is extremely rare, with fewer than 50 cases reported in the literature. It can occur at any age, but is most commonly diagnosed in adults between the ages of 30 and 60. There is no known gender or racial predilection.
Pathogenesis[edit]
The exact cause of malignant chondroid syringoma is unknown. It is believed to arise from the eccrine sweat glands, which are a type of sweat gland found throughout the body. The tumor is composed of both epithelial and mesenchymal components, reflecting its mixed origin.
Clinical Features[edit]
Patients with malignant chondroid syringoma typically present with a slow-growing, painless nodule on the skin. The most common locations are the head and neck, but the tumor can occur anywhere on the body. Other symptoms may include ulceration of the skin and regional lymphadenopathy.
Diagnosis[edit]
The diagnosis of malignant chondroid syringoma is made based on the clinical presentation and histopathological examination of the tumor. Immunohistochemistry may be used to confirm the diagnosis. The tumor cells typically express markers of both epithelial and mesenchymal differentiation.
Treatment[edit]
The mainstay of treatment for malignant chondroid syringoma is surgical excision of the tumor. Radiation therapy and chemotherapy may be used in cases where the tumor is not completely resectable or has metastasized to other parts of the body.
Prognosis[edit]
The prognosis of malignant chondroid syringoma is generally poor due to its aggressive nature and tendency to recur and metastasize. The 5-year survival rate is estimated to be less than 50%.
See Also[edit]
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