Lupus pernio: Difference between revisions
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{{Infobox medical condition | |||
== | | name = Lupus pernio | ||
| image = [[File:Lupus_pernio_01.jpg]] | |||
| caption = Lupus pernio on the nose | |||
== | | field = [[Dermatology]] | ||
The exact cause of lupus pernio is unknown | | synonyms = Sarcoidosis of the skin | ||
| symptoms = [[Chronic]] [[skin lesions]] on the [[face]], especially the [[nose]], [[cheeks]], [[ears]], and [[lips]] | |||
== Diagnosis == | | complications = [[Disfigurement]], [[respiratory issues]] | ||
| onset = [[Adulthood]] | |||
| duration = [[Chronic]] | |||
== Treatment == | | causes = Unknown, associated with [[sarcoidosis]] | ||
Treatment | | risks = [[African descent]], [[Scandinavian descent]], [[female]] | ||
| diagnosis = [[Clinical examination]], [[biopsy]] | |||
== Prognosis == | | differential = [[Lupus vulgaris]], [[rosacea]], [[chronic granulomatous disease]] | ||
The prognosis | | treatment = [[Corticosteroids]], [[immunosuppressive drugs]] | ||
| prognosis = Variable, often chronic | |||
== See also == | | frequency = Rare | ||
}} | |||
{{Short description|A detailed overview of Lupus Pernio}} | |||
==Lupus Pernio== | |||
[[File:Lupus_pernio_01.jpg|left|thumb|Lupus pernio affecting the nose and cheeks]] | |||
'''Lupus pernio''' is a chronic, disfiguring skin condition associated with [[sarcoidosis]]. It is characterized by violaceous, raised lesions that typically appear on the face, particularly the nose, cheeks, lips, and ears. The condition is named for its resemblance to the lesions seen in [[lupus vulgaris]], although it is not related to [[lupus erythematosus]]. | |||
==Pathophysiology== | |||
Lupus pernio is a manifestation of [[sarcoidosis]], a systemic inflammatory disease characterized by the formation of non-caseating [[granulomas]] in various organs. The exact cause of sarcoidosis and lupus pernio is unknown, but it is believed to involve an abnormal immune response to an unknown antigen. The skin lesions in lupus pernio are thought to result from granulomatous inflammation in the dermis. | |||
==Clinical Presentation== | |||
Patients with lupus pernio typically present with chronic, indurated, violaceous plaques on the face. These lesions are often asymptomatic but can be disfiguring and may lead to cosmetic concerns. The lesions are usually persistent and may slowly enlarge over time. In some cases, lupus pernio can be associated with other systemic manifestations of sarcoidosis, such as [[pulmonary sarcoidosis]], [[uveitis]], or [[cardiac sarcoidosis]]. | |||
==Diagnosis== | |||
The diagnosis of lupus pernio is primarily clinical, based on the characteristic appearance of the skin lesions. A skin [[biopsy]] can be performed to confirm the presence of non-caseating granulomas, which are indicative of sarcoidosis. Additional tests, such as chest [[X-ray]] or [[CT scan]], may be conducted to assess for systemic involvement of sarcoidosis. | |||
==Treatment== | |||
Treatment of lupus pernio can be challenging, as the lesions are often resistant to therapy. The mainstay of treatment is systemic [[corticosteroids]], which can help reduce inflammation and improve the appearance of the lesions. Other treatments that may be used include [[methotrexate]], [[hydroxychloroquine]], and [[tumor necrosis factor (TNF) inhibitors]]. In some cases, [[laser therapy]] or surgical excision may be considered for cosmetic improvement. | |||
==Prognosis== | |||
The prognosis of lupus pernio varies depending on the extent of the disease and the response to treatment. While the condition is chronic and can be disfiguring, it is not life-threatening. With appropriate management, many patients can achieve significant improvement in their symptoms and quality of life. | |||
==See also== | |||
* [[Sarcoidosis]] | * [[Sarcoidosis]] | ||
* [[Granuloma]] | * [[Granuloma]] | ||
* [[Lupus vulgaris]] | |||
* [[Lupus erythematosus]] | |||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category: | [[Category:Sarcoidosis]] | ||
Latest revision as of 22:34, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Lupus pernio | |
|---|---|
| |
| Synonyms | Sarcoidosis of the skin |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Chronic skin lesions on the face, especially the nose, cheeks, ears, and lips |
| Complications | Disfigurement, respiratory issues |
| Onset | Adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, associated with sarcoidosis |
| Risks | African descent, Scandinavian descent, female |
| Diagnosis | Clinical examination, biopsy |
| Differential diagnosis | Lupus vulgaris, rosacea, chronic granulomatous disease |
| Prevention | N/A |
| Treatment | Corticosteroids, immunosuppressive drugs |
| Medication | N/A |
| Prognosis | Variable, often chronic |
| Frequency | Rare |
| Deaths | N/A |
A detailed overview of Lupus Pernio
Lupus Pernio[edit]
Lupus pernio is a chronic, disfiguring skin condition associated with sarcoidosis. It is characterized by violaceous, raised lesions that typically appear on the face, particularly the nose, cheeks, lips, and ears. The condition is named for its resemblance to the lesions seen in lupus vulgaris, although it is not related to lupus erythematosus.
Pathophysiology[edit]
Lupus pernio is a manifestation of sarcoidosis, a systemic inflammatory disease characterized by the formation of non-caseating granulomas in various organs. The exact cause of sarcoidosis and lupus pernio is unknown, but it is believed to involve an abnormal immune response to an unknown antigen. The skin lesions in lupus pernio are thought to result from granulomatous inflammation in the dermis.
Clinical Presentation[edit]
Patients with lupus pernio typically present with chronic, indurated, violaceous plaques on the face. These lesions are often asymptomatic but can be disfiguring and may lead to cosmetic concerns. The lesions are usually persistent and may slowly enlarge over time. In some cases, lupus pernio can be associated with other systemic manifestations of sarcoidosis, such as pulmonary sarcoidosis, uveitis, or cardiac sarcoidosis.
Diagnosis[edit]
The diagnosis of lupus pernio is primarily clinical, based on the characteristic appearance of the skin lesions. A skin biopsy can be performed to confirm the presence of non-caseating granulomas, which are indicative of sarcoidosis. Additional tests, such as chest X-ray or CT scan, may be conducted to assess for systemic involvement of sarcoidosis.
Treatment[edit]
Treatment of lupus pernio can be challenging, as the lesions are often resistant to therapy. The mainstay of treatment is systemic corticosteroids, which can help reduce inflammation and improve the appearance of the lesions. Other treatments that may be used include methotrexate, hydroxychloroquine, and tumor necrosis factor (TNF) inhibitors. In some cases, laser therapy or surgical excision may be considered for cosmetic improvement.
Prognosis[edit]
The prognosis of lupus pernio varies depending on the extent of the disease and the response to treatment. While the condition is chronic and can be disfiguring, it is not life-threatening. With appropriate management, many patients can achieve significant improvement in their symptoms and quality of life.
