Thallium poisoning

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Thallium poisoning
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Nausea, vomiting, diarrhea, hair loss, peripheral neuropathy, organ failure
Complications	Multi-organ failure, death
Onset	Hours to days after exposure
Duration	Variable, depending on exposure and treatment
Types	N/A
Causes	Exposure to thallium compounds
Risks	Industrial exposure, contaminated food or water, intentional poisoning
Diagnosis	Blood test, urine test for thallium levels
Differential diagnosis	Arsenic poisoning, lead poisoning, mercury poisoning
Prevention	Avoidance of thallium exposure, proper industrial safety measures
Treatment	Prussian blue, activated charcoal, supportive care
Medication	N/A
Prognosis	Variable; better with early treatment
Frequency	Rare
Deaths	N/A

Overview of thallium poisoning, its symptoms, diagnosis, and treatment

Thallium poisoning is a rare but serious condition caused by exposure to thallium, a heavy metal that is highly toxic to humans. Thallium can enter the body through ingestion, inhalation, or skin contact, and it is often used in rodenticides and insecticides, although its use has declined due to its toxicity.

Symptoms

The symptoms of thallium poisoning can vary depending on the level and duration of exposure. Common symptoms include:

• Gastrointestinal distress, such as nausea, vomiting, and diarrhea.
• Neurological symptoms, including peripheral neuropathy, ataxia, and tremors.
• Alopecia, or hair loss, which is a distinctive sign of thallium poisoning.
• Cardiovascular issues, such as hypertension and tachycardia.
• Renal dysfunction, leading to kidney damage.

Diagnosis

Diagnosing thallium poisoning can be challenging due to its nonspecific symptoms. However, a detailed patient history and laboratory tests can aid in diagnosis. Key diagnostic methods include:

• Measuring thallium levels in the blood and urine.
• Electromyography (EMG) to assess nerve damage.
• Hair analysis to detect thallium, as it accumulates in hair.

Treatment

Treatment for thallium poisoning involves removing the source of exposure and administering therapies to reduce thallium levels in the body. Common treatments include:

• Prussian blue, an oral chelating agent that binds to thallium and enhances its excretion.
• Supportive care to manage symptoms, such as hydration therapy and pain management.
• Hemodialysis in severe cases to remove thallium from the bloodstream.

Prevention

Preventing thallium poisoning involves minimizing exposure to thallium-containing substances. This can be achieved by:

• Using alternative, less toxic substances in industrial and agricultural settings.
• Implementing strict safety protocols for handling thallium.
• Educating the public and workers about the risks of thallium exposure.

See also

• Heavy metal poisoning
• Chelation therapy
• Toxicology