Malignant acrospiroma: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
== | | name = Malignant acrospiroma | ||
| image = [[File:SkinTumors-P8110599.JPG|left|thumb|Malignant acrospiroma on the skin]] | |||
| caption = Malignant acrospiroma on the skin | |||
| synonyms = [[Aggressive digital papillary adenocarcinoma]], [[Aggressive digital papillary adenoma]], [[Aggressive digital papillary adenoma/carcinoma]] | |||
| specialty = [[Dermatology]], [[Oncology]] | |||
| symptoms = [[Skin nodule]], [[Ulceration]], [[Pain]] | |||
| complications = [[Metastasis]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic]] | |||
| causes = Unknown | |||
| risks = [[Genetic predisposition]], [[Environmental factors]] | |||
| diagnosis = [[Biopsy]], [[Histopathology]] | |||
| differential = [[Benign acrospiroma]], [[Squamous cell carcinoma]], [[Basal cell carcinoma]] | |||
| treatment = [[Surgical excision]], [[Radiation therapy]], [[Chemotherapy]] | |||
| prognosis = Variable, depends on stage and metastasis | |||
| frequency = Rare | |||
}} | |||
{{DISPLAYTITLE:Malignant Acrospiroma}} | |||
Malignant acrospiroma, also known as malignant [[hidradenoma]], is a rare type of [[skin cancer]] that originates from the [[sweat glands]]. It is considered a type of [[eccrine sweat gland tumor]] and is characterized by its aggressive behavior and potential to metastasize. | |||
== Pathophysiology == | |||
Malignant acrospiromas arise from the [[eccrine sweat glands]], which are responsible for thermoregulation through the secretion of sweat. These tumors can occur anywhere on the body but are most commonly found on the [[head]], [[neck]], and [[extremities]]. The exact cause of malignant acrospiroma is not well understood, but it is believed to involve genetic mutations that lead to uncontrolled cell growth. | |||
== Clinical Presentation == | |||
Patients with malignant acrospiroma typically present with a solitary, firm, and sometimes painful nodule on the skin. The lesion may be skin-colored, erythematous, or bluish. Over time, the tumor can ulcerate and bleed. Due to its aggressive nature, malignant acrospiroma can invade surrounding tissues and metastasize to distant organs, including the [[lungs]], [[liver]], and [[lymph nodes]]. | |||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of malignant acrospiroma is primarily based on histological examination. A biopsy of the lesion is performed, and the tissue is examined under a microscope. Histologically, malignant acrospiromas show atypical cells with high mitotic activity and areas of necrosis. Immunohistochemical staining can aid in differentiating it from other skin tumors. | |||
== Treatment == | == Treatment == | ||
The primary treatment for malignant acrospiroma is surgical excision with wide margins to ensure complete removal of the tumor. In cases where the tumor has metastasized, additional treatments such as [[radiation therapy]] or [[chemotherapy]] may be considered. Due to the rarity of the condition, there is no standardized treatment protocol, and management is often individualized. | |||
== Prognosis == | |||
The prognosis for patients with malignant acrospiroma varies depending on the stage at diagnosis and the presence of metastasis. Early detection and complete surgical excision can lead to a favorable outcome. However, once the tumor has metastasized, the prognosis becomes poor. | |||
== See also == | == See also == | ||
* [[Hidradenoma]] | |||
* [[Eccrine sweat gland]] | |||
* [[Skin cancer]] | * [[Skin cancer]] | ||
* [[ | * [[Tumor]] | ||
[[Category:Skin neoplasms]] | |||
[[Category:Rare cancers]] | |||
[[Category:Skin | |||
[[Category:Rare | |||
Latest revision as of 04:04, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Malignant acrospiroma | |
|---|---|
 | |
| Synonyms | Aggressive digital papillary adenocarcinoma, Aggressive digital papillary adenoma, Aggressive digital papillary adenoma/carcinoma |
| Pronounce | N/A |
| Specialty | Dermatology, Oncology |
| Symptoms | Skin nodule, Ulceration, Pain |
| Complications | Metastasis |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown |
| Risks | Genetic predisposition, Environmental factors |
| Diagnosis | Biopsy, Histopathology |
| Differential diagnosis | Benign acrospiroma, Squamous cell carcinoma, Basal cell carcinoma |
| Prevention | N/A |
| Treatment | Surgical excision, Radiation therapy, Chemotherapy |
| Medication | N/A |
| Prognosis | Variable, depends on stage and metastasis |
| Frequency | Rare |
| Deaths | N/A |
Malignant acrospiroma, also known as malignant hidradenoma, is a rare type of skin cancer that originates from the sweat glands. It is considered a type of eccrine sweat gland tumor and is characterized by its aggressive behavior and potential to metastasize.
Pathophysiology[edit]
Malignant acrospiromas arise from the eccrine sweat glands, which are responsible for thermoregulation through the secretion of sweat. These tumors can occur anywhere on the body but are most commonly found on the head, neck, and extremities. The exact cause of malignant acrospiroma is not well understood, but it is believed to involve genetic mutations that lead to uncontrolled cell growth.
Clinical Presentation[edit]
Patients with malignant acrospiroma typically present with a solitary, firm, and sometimes painful nodule on the skin. The lesion may be skin-colored, erythematous, or bluish. Over time, the tumor can ulcerate and bleed. Due to its aggressive nature, malignant acrospiroma can invade surrounding tissues and metastasize to distant organs, including the lungs, liver, and lymph nodes.
Diagnosis[edit]
The diagnosis of malignant acrospiroma is primarily based on histological examination. A biopsy of the lesion is performed, and the tissue is examined under a microscope. Histologically, malignant acrospiromas show atypical cells with high mitotic activity and areas of necrosis. Immunohistochemical staining can aid in differentiating it from other skin tumors.
Treatment[edit]
The primary treatment for malignant acrospiroma is surgical excision with wide margins to ensure complete removal of the tumor. In cases where the tumor has metastasized, additional treatments such as radiation therapy or chemotherapy may be considered. Due to the rarity of the condition, there is no standardized treatment protocol, and management is often individualized.
Prognosis[edit]
The prognosis for patients with malignant acrospiroma varies depending on the stage at diagnosis and the presence of metastasis. Early detection and complete surgical excision can lead to a favorable outcome. However, once the tumor has metastasized, the prognosis becomes poor.
