MODY 4: Difference between revisions
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{{Infobox medical condition | |||
| name = Maturity onset diabetes of the young type 4 | |||
| synonyms = MODY 4 | |||
| field = [[Endocrinology]] | |||
| symptoms = [[Hyperglycemia]], [[polyuria]], [[polydipsia]], [[weight loss]] | |||
| complications = [[Diabetic ketoacidosis]], [[microvascular complications]] | |||
| onset = Typically in [[adolescence]] or [[early adulthood]] | |||
| duration = [[Chronic condition|Chronic]] | |||
| causes = [[Genetic mutation]] in the [[PDX1]] gene | |||
| risks = [[Family history]] of [[diabetes]] | |||
| diagnosis = [[Genetic testing]], [[blood glucose]] tests | |||
| differential = [[Type 1 diabetes]], [[Type 2 diabetes]], other forms of [[MODY]] | |||
| treatment = [[Dietary management]], [[oral hypoglycemic agents]], [[insulin therapy]] | |||
| medication = [[Sulfonylureas]], [[Metformin]], [[Insulin]] | |||
| prognosis = Variable, depending on [[glycemic control]] | |||
| frequency = Rare, less than 1% of all [[diabetes mellitus]] cases | |||
}} | |||
'''MODY 4''' is a form of [[Maturity onset diabetes of the young]] (MODY), which is a group of inherited forms of [[diabetes mellitus]]. It is caused by mutations in the [[PDX1]] gene. | '''MODY 4''' is a form of [[Maturity onset diabetes of the young]] (MODY), which is a group of inherited forms of [[diabetes mellitus]]. It is caused by mutations in the [[PDX1]] gene. | ||
==Overview== | ==Overview== | ||
MODY 4 is a rare form of MODY, with fewer than 1% of all MODY cases being MODY 4. It is characterized by the onset of hyperglycemia at an early age (often before 25 years of age), a primary defect in insulin secretion and a strong inheritance pattern. | MODY 4 is a rare form of MODY, with fewer than 1% of all MODY cases being MODY 4. It is characterized by the onset of hyperglycemia at an early age (often before 25 years of age), a primary defect in insulin secretion and a strong inheritance pattern. | ||
==Causes== | ==Causes== | ||
MODY 4 is caused by mutations in the PDX1 gene. This gene provides instructions for making a protein that is involved in the development of the pancreas. The PDX1 protein also helps regulate the production of insulin, a hormone that controls blood sugar levels. | MODY 4 is caused by mutations in the PDX1 gene. This gene provides instructions for making a protein that is involved in the development of the pancreas. The PDX1 protein also helps regulate the production of insulin, a hormone that controls blood sugar levels. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of MODY 4 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, because MODY 4 often develops at a young age, these symptoms may be mistaken for those of type 1 diabetes. | The symptoms of MODY 4 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, because MODY 4 often develops at a young age, these symptoms may be mistaken for those of type 1 diabetes. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of MODY 4 is based on the presence of persistent hyperglycemia, a family history of diabetes, and the identification of a mutation in the PDX1 gene. Genetic testing is necessary to confirm the diagnosis. | The diagnosis of MODY 4 is based on the presence of persistent hyperglycemia, a family history of diabetes, and the identification of a mutation in the PDX1 gene. Genetic testing is necessary to confirm the diagnosis. | ||
==Treatment== | ==Treatment== | ||
The treatment of MODY 4 involves managing blood sugar levels through a combination of diet, exercise, and medication. Some people with MODY 4 may require insulin injections. | The treatment of MODY 4 involves managing blood sugar levels through a combination of diet, exercise, and medication. Some people with MODY 4 may require insulin injections. | ||
==See also== | ==See also== | ||
* [[Maturity onset diabetes of the young]] | * [[Maturity onset diabetes of the young]] | ||
* [[Diabetes mellitus]] | * [[Diabetes mellitus]] | ||
* [[PDX1]] | * [[PDX1]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Diabetes]] | [[Category:Diabetes]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Endocrine diseases]] | [[Category:Endocrine diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 05:19, 4 April 2025
| Maturity onset diabetes of the young type 4 | |
|---|---|
| Synonyms | MODY 4 |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Hyperglycemia, polyuria, polydipsia, weight loss |
| Complications | Diabetic ketoacidosis, microvascular complications |
| Onset | Typically in adolescence or early adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation in the PDX1 gene |
| Risks | Family history of diabetes |
| Diagnosis | Genetic testing, blood glucose tests |
| Differential diagnosis | Type 1 diabetes, Type 2 diabetes, other forms of MODY |
| Prevention | N/A |
| Treatment | Dietary management, oral hypoglycemic agents, insulin therapy |
| Medication | Sulfonylureas, Metformin, Insulin |
| Prognosis | Variable, depending on glycemic control |
| Frequency | Rare, less than 1% of all diabetes mellitus cases |
| Deaths | N/A |
MODY 4 is a form of Maturity onset diabetes of the young (MODY), which is a group of inherited forms of diabetes mellitus. It is caused by mutations in the PDX1 gene.
Overview[edit]
MODY 4 is a rare form of MODY, with fewer than 1% of all MODY cases being MODY 4. It is characterized by the onset of hyperglycemia at an early age (often before 25 years of age), a primary defect in insulin secretion and a strong inheritance pattern.
Causes[edit]
MODY 4 is caused by mutations in the PDX1 gene. This gene provides instructions for making a protein that is involved in the development of the pancreas. The PDX1 protein also helps regulate the production of insulin, a hormone that controls blood sugar levels.
Symptoms[edit]
The symptoms of MODY 4 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, because MODY 4 often develops at a young age, these symptoms may be mistaken for those of type 1 diabetes.
Diagnosis[edit]
The diagnosis of MODY 4 is based on the presence of persistent hyperglycemia, a family history of diabetes, and the identification of a mutation in the PDX1 gene. Genetic testing is necessary to confirm the diagnosis.
Treatment[edit]
The treatment of MODY 4 involves managing blood sugar levels through a combination of diet, exercise, and medication. Some people with MODY 4 may require insulin injections.
See also[edit]
References[edit]
<references />
