MODY 3: Difference between revisions
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{{Infobox medical condition | |||
| name = MODY 3 | |||
| synonyms = Maturity onset diabetes of the young type 3 | |||
| field = [[Endocrinology]] | |||
| symptoms = [[Hyperglycemia]], [[polyuria]], [[polydipsia]], [[weight loss]] | |||
| complications = [[Diabetic retinopathy]], [[nephropathy]], [[neuropathy]] | |||
| onset = Typically in [[adolescence]] or early [[adulthood]] | |||
| duration = Chronic | |||
| causes = [[Genetic mutation]] in the [[HNF1A]] gene | |||
| risks = Family history of [[diabetes]] | |||
| diagnosis = [[Genetic testing]], [[blood glucose]] tests | |||
| differential = [[Type 1 diabetes]], [[Type 2 diabetes]] | |||
| treatment = [[Dietary management]], [[oral hypoglycemic agents]] | |||
| medication = [[Sulfonylureas]], [[insulin]] (if necessary) | |||
| prognosis = Variable, depending on management | |||
| frequency = Accounts for 1-2% of all diabetes cases | |||
}} | |||
'''MODY 3''' is a form of [[Maturity onset diabetes of the young]] (MODY), which is a group of inherited forms of [[diabetes mellitus]]. It is caused by mutations in the [[HNF1A]] gene. | '''MODY 3''' is a form of [[Maturity onset diabetes of the young]] (MODY), which is a group of inherited forms of [[diabetes mellitus]]. It is caused by mutations in the [[HNF1A]] gene. | ||
==Overview== | ==Overview== | ||
MODY 3 is the most common form of MODY. It is characterized by an onset usually before the age of 25, a primary defect in insulin secretion and a strong inheritance pattern. The disease is caused by mutations in the HNF1A gene, which encodes a transcription factor that regulates the expression of several liver-specific genes. | MODY 3 is the most common form of MODY. It is characterized by an onset usually before the age of 25, a primary defect in insulin secretion and a strong inheritance pattern. The disease is caused by mutations in the HNF1A gene, which encodes a transcription factor that regulates the expression of several liver-specific genes. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of MODY 3 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, MODY 3 often goes undiagnosed because the symptoms are mild or absent. | The symptoms of MODY 3 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, MODY 3 often goes undiagnosed because the symptoms are mild or absent. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of MODY 3 is based on clinical features and genetic testing. The presence of diabetes in multiple generations, the onset of diabetes at a young age, and the absence of obesity or other risk factors for type 2 diabetes suggest the diagnosis of MODY 3. | The diagnosis of MODY 3 is based on clinical features and genetic testing. The presence of diabetes in multiple generations, the onset of diabetes at a young age, and the absence of obesity or other risk factors for type 2 diabetes suggest the diagnosis of MODY 3. | ||
==Treatment== | ==Treatment== | ||
The treatment of MODY 3 involves lifestyle modifications and medication. Patients with MODY 3 often respond well to low doses of sulfonylureas, which stimulate the release of insulin from the pancreas. | The treatment of MODY 3 involves lifestyle modifications and medication. Patients with MODY 3 often respond well to low doses of sulfonylureas, which stimulate the release of insulin from the pancreas. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of MODY 3 is generally good, but patients are at risk for long-term complications of diabetes, including heart disease, kidney disease, and eye disease. | The prognosis of MODY 3 is generally good, but patients are at risk for long-term complications of diabetes, including heart disease, kidney disease, and eye disease. | ||
==See also== | ==See also== | ||
* [[Maturity onset diabetes of the young]] | * [[Maturity onset diabetes of the young]] | ||
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* [[Diabetes mellitus]] | * [[Diabetes mellitus]] | ||
* [[Sulfonylurea]] | * [[Sulfonylurea]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Diabetes]] | [[Category:Diabetes]] | ||
[[Category:Genetic diseases]] | [[Category:Genetic diseases]] | ||
[[Category:Endocrine diseases]] | [[Category:Endocrine diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 02:12, 4 April 2025
| MODY 3 | |
|---|---|
| Synonyms | Maturity onset diabetes of the young type 3 |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Hyperglycemia, polyuria, polydipsia, weight loss |
| Complications | Diabetic retinopathy, nephropathy, neuropathy |
| Onset | Typically in adolescence or early adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation in the HNF1A gene |
| Risks | Family history of diabetes |
| Diagnosis | Genetic testing, blood glucose tests |
| Differential diagnosis | Type 1 diabetes, Type 2 diabetes |
| Prevention | N/A |
| Treatment | Dietary management, oral hypoglycemic agents |
| Medication | Sulfonylureas, insulin (if necessary) |
| Prognosis | Variable, depending on management |
| Frequency | Accounts for 1-2% of all diabetes cases |
| Deaths | N/A |
MODY 3 is a form of Maturity onset diabetes of the young (MODY), which is a group of inherited forms of diabetes mellitus. It is caused by mutations in the HNF1A gene.
Overview[edit]
MODY 3 is the most common form of MODY. It is characterized by an onset usually before the age of 25, a primary defect in insulin secretion and a strong inheritance pattern. The disease is caused by mutations in the HNF1A gene, which encodes a transcription factor that regulates the expression of several liver-specific genes.
Symptoms[edit]
The symptoms of MODY 3 are similar to those of other forms of diabetes, including frequent urination, excessive thirst, fatigue, blurred vision, and weight loss. However, MODY 3 often goes undiagnosed because the symptoms are mild or absent.
Diagnosis[edit]
The diagnosis of MODY 3 is based on clinical features and genetic testing. The presence of diabetes in multiple generations, the onset of diabetes at a young age, and the absence of obesity or other risk factors for type 2 diabetes suggest the diagnosis of MODY 3.
Treatment[edit]
The treatment of MODY 3 involves lifestyle modifications and medication. Patients with MODY 3 often respond well to low doses of sulfonylureas, which stimulate the release of insulin from the pancreas.
Prognosis[edit]
The prognosis of MODY 3 is generally good, but patients are at risk for long-term complications of diabetes, including heart disease, kidney disease, and eye disease.
See also[edit]
References[edit]
<references />
