Ethinylestradiol/drospirenone: Difference between revisions
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{{Short description|Combination hormonal contraceptive}} | |||
{{Drugbox | |||
| verifiedrevid = 464384123 | |||
| type = combo | |||
| component1 = [[Ethinylestradiol]] | |||
| class1 = Estrogen | |||
| component2 = [[Drospirenone]] | |||
| class2 = Progestin | |||
}} | |||
'''Ethinylestradiol/drospirenone''' is a combination [[hormonal contraceptive]] used in [[birth control]] pills. It contains two active ingredients: [[ethinylestradiol]], an [[estrogen]], and [[drospirenone]], a [[progestin]]. This combination is used to prevent [[pregnancy]] and is also prescribed for other medical conditions such as [[acne]] and [[premenstrual dysphoric disorder]] (PMDD). | |||
==Pharmacology== | |||
== | ===Ethinylestradiol=== | ||
[[File:Ethinylestradiol.svg|thumb|right|Ethinylestradiol]] | |||
Ethinylestradiol is a synthetic form of [[estrogen]] that is commonly used in [[oral contraceptives]]. It works by inhibiting [[ovulation]] through suppression of the [[hypothalamic-pituitary-ovarian axis]]. Ethinylestradiol also causes changes in the [[cervical mucus]] and [[endometrium]], making it more difficult for [[sperm]] to enter the [[uterus]] and for a [[fertilized egg]] to implant. | |||
===Drospirenone=== | |||
[[File:Drospirenone.svg|thumb|left|Drospirenone]] | |||
Drospirenone is a synthetic [[progestin]] with anti-mineralocorticoid and anti-androgenic properties. It is structurally related to [[spironolactone]], a [[diuretic]] and [[antihypertensive]] medication. Drospirenone helps to prevent [[ovulation]] and also contributes to the contraceptive effect by altering the [[endometrium]] and [[cervical mucus]]. Its anti-androgenic effects can be beneficial in treating [[acne]] and [[hirsutism]]. | |||
== | ==Medical Uses== | ||
Ethinylestradiol/drospirenone is primarily used as a [[contraceptive]] to prevent [[pregnancy]]. It is also prescribed for the treatment of moderate [[acne]] in women who desire oral contraception, and for the management of [[premenstrual dysphoric disorder]] (PMDD). Additionally, it can be used to regulate [[menstrual cycles]] and reduce [[menstrual pain]]. | |||
Common side effects of ethinylestradiol/drospirenone include nausea, | ==Side Effects== | ||
Common side effects of ethinylestradiol/drospirenone include [[nausea]], [[headache]], [[breast tenderness]], and [[mood changes]]. Serious side effects can include an increased risk of [[blood clots]], [[stroke]], and [[heart attack]], particularly in women who smoke and are over 35 years of age. It is important for patients to discuss their medical history and risk factors with their healthcare provider before starting this medication. | |||
== | ==Contraindications== | ||
Ethinylestradiol/drospirenone is contraindicated in women with a history of [[thromboembolic disorders]], [[breast cancer]], [[liver disease]], and [[uncontrolled hypertension]]. It should not be used by women who are pregnant or breastfeeding. | |||
==Related Pages== | |||
* [[Hormonal contraception]] | |||
* [[Oral contraceptive pill]] | * [[Oral contraceptive pill]] | ||
* [[ | * [[Estrogen]] | ||
* [[ | * [[Progestin]] | ||
* [[Acne]] | |||
[[ | * [[Premenstrual dysphoric disorder]] | ||
[[ | |||
[[Category:Combined oral contraceptives]] | |||
[[Category:Estrogens]] | |||
[[Category:Progestogens]] | |||
Latest revision as of 11:10, 23 March 2025
Combination hormonal contraceptive
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Ethinylestradiol/drospirenone is a combination hormonal contraceptive used in birth control pills. It contains two active ingredients: ethinylestradiol, an estrogen, and drospirenone, a progestin. This combination is used to prevent pregnancy and is also prescribed for other medical conditions such as acne and premenstrual dysphoric disorder (PMDD).
Pharmacology[edit]
Ethinylestradiol[edit]
Ethinylestradiol is a synthetic form of estrogen that is commonly used in oral contraceptives. It works by inhibiting ovulation through suppression of the hypothalamic-pituitary-ovarian axis. Ethinylestradiol also causes changes in the cervical mucus and endometrium, making it more difficult for sperm to enter the uterus and for a fertilized egg to implant.
Drospirenone[edit]
Drospirenone is a synthetic progestin with anti-mineralocorticoid and anti-androgenic properties. It is structurally related to spironolactone, a diuretic and antihypertensive medication. Drospirenone helps to prevent ovulation and also contributes to the contraceptive effect by altering the endometrium and cervical mucus. Its anti-androgenic effects can be beneficial in treating acne and hirsutism.
Medical Uses[edit]
Ethinylestradiol/drospirenone is primarily used as a contraceptive to prevent pregnancy. It is also prescribed for the treatment of moderate acne in women who desire oral contraception, and for the management of premenstrual dysphoric disorder (PMDD). Additionally, it can be used to regulate menstrual cycles and reduce menstrual pain.
Side Effects[edit]
Common side effects of ethinylestradiol/drospirenone include nausea, headache, breast tenderness, and mood changes. Serious side effects can include an increased risk of blood clots, stroke, and heart attack, particularly in women who smoke and are over 35 years of age. It is important for patients to discuss their medical history and risk factors with their healthcare provider before starting this medication.
Contraindications[edit]
Ethinylestradiol/drospirenone is contraindicated in women with a history of thromboembolic disorders, breast cancer, liver disease, and uncontrolled hypertension. It should not be used by women who are pregnant or breastfeeding.
