CD38: Difference between revisions

Latest revision as of 18:24, 18 March 2025

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4, CD8, B cells and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

Function[edit]

CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. This molecule is necessary for the regulation of intracellular calcium.

Clinical significance[edit]

CD38 has been used as a prognostic marker in leukemia. It is also a target of the drug Daratumumab, which is used in the treatment of multiple myeloma.

References[edit]

External links[edit]

CD38 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article is a medical stub. You can help WikiMD by expanding it!
Most recent articles Ongoing trials	Wikipedia

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Revision as of 23:15, 25 February 2024 edit Prab (talk \| contribs) , Bureaucrats, Interface administrators, Administrators 1,432,208 edits CSV import Tags: mobile edit mobile web edit		Latest revision as of 18:24, 18 March 2025 edit undo Prab (talk \| contribs) , Bureaucrats, Interface administrators, Administrators 1,432,208 edits No edit summary Tag: Manual revert
(2 intermediate revisions by the same user not shown)
Line 23:		Line 23:

	This article incorporates text from the [[United States National Library of Medicine]], which is in the public domain.		This article incorporates text from the [[United States National Library of Medicine]], which is in the public domain.
			{{No image}}