Immunogenetics: Difference between revisions
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Latest revision as of 12:49, 18 March 2025
Immunogenetics is the branch of medical genetics that explores the relationship between the immune system and genetics. This field of study is significant in understanding the pathogenesis of several diseases that involve the immune system, and it also aids in the development of novel therapeutic strategies for such diseases.
Overview[edit]
Immunogenetics focuses on the ways in which genetic factors influence the immune response. This includes the study of normal immunological function and the identification of genetic variations that can lead to immune disorders. The field encompasses a wide range of disorders, including autoimmune diseases, allergies, and cancer, as well as the genetic basis of immune response to infectious diseases and transplantation.
History[edit]
The field of immunogenetics emerged in the mid-20th century, following the discovery of the major histocompatibility complex (MHC) in mice. This complex, which is crucial for immune response, was later found in humans and named the human leukocyte antigen (HLA) system.
Major Areas of Study[edit]
Major Histocompatibility Complex[edit]
The MHC, or HLA in humans, is a key area of study in immunogenetics. These genes encode proteins that help the immune system distinguish between self and non-self cells. Variations in these genes can affect susceptibility to various diseases.
Immunoglobulin Genetics[edit]
Immunoglobulins, or antibodies, are proteins produced by the immune system to fight off infections. The genes that encode these proteins are another major focus of immunogenetics.
T Cell Receptor Genetics[edit]
T cells are a type of white blood cell that play a crucial role in the immune response. The genes that encode the T cell receptor, which recognizes and binds to foreign antigens, are another important area of study in immunogenetics.
Clinical Applications[edit]
Immunogenetics has numerous clinical applications, including in the diagnosis and treatment of immune disorders, the development of vaccines, and in transplantation medicine. For example, HLA typing is used to match donors and recipients for organ transplantation.
See Also[edit]
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