2-Methoxyestradiol disulfamate: Difference between revisions

Latest revision as of 23:55, 24 February 2025

2-Methoxyestradiol disulfamate is a synthetic estrogen derivative that has been studied for its potential use in cancer therapy. It is a sulfamoylated analog of 2-Methoxyestradiol, a naturally occurring metabolite of estradiol.

Chemical Properties[edit]

2-Methoxyestradiol disulfamate is characterized by the addition of sulfamate groups to the 2-methoxyestradiol molecule. This modification enhances its bioavailability and pharmacokinetics, making it a more potent agent in inhibiting tumor growth.

Mechanism of Action[edit]

The compound acts by disrupting the microtubule network within cancer cells, leading to cell cycle arrest and apoptosis. It also inhibits angiogenesis, the process by which new blood vessels form from pre-existing vessels, which is crucial for tumor growth and metastasis.

Therapeutic Potential[edit]

2-Methoxyestradiol disulfamate has shown promise in preclinical studies as an anti-cancer agent. It is particularly effective against breast cancer, prostate cancer, and ovarian cancer. Its ability to target multiple pathways involved in cancer progression makes it a candidate for further clinical development.

Related Compounds[edit]

Related Pages[edit]

STX-140 chemical structure

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-{{Short description|A synthetic estrogen derivative}}
 {{DISPLAYTITLE:2-Methoxyestradiol disulfamate}}
+'''2-Methoxyestradiol disulfamate''' is a synthetic [[estrogen]] derivative that has been studied for its potential use in [[cancer]] therapy. It is a sulfamoylated analog of [[2-Methoxyestradiol]], a naturally occurring [[metabolite]] of [[estradiol]].
-'''2-Methoxyestradiol disulfamate''' (STX-140) is a synthetic [[estrogen]] derivative that has been studied for its potential use in the treatment of various [[cancer]]s. It is a [[sulfamate]] derivative of [[2-methoxyestradiol]], a naturally occurring [[estrogen metabolite]].
+== Chemical Properties ==
-==Chemical structure and properties==
+-Methoxyestradiol disulfamate is characterized by the addition of sulfamate groups to the 2-methoxyestradiol molecule. This modification enhances its [[bioavailability]] and [[pharmacokinetics]], making it a more potent agent in inhibiting [[tumor]] growth.
--Methoxyestradiol disulfamate is a [[sulfamate ester]] of 2-methoxyestradiol. The addition of the sulfamate groups is intended to improve the bioavailability and metabolic stability of the compound compared to its parent compound, 2-methoxyestradiol.
-==Mechanism of action==
+== Mechanism of Action ==
--Methoxyestradiol disulfamate acts by disrupting the [[microtubule]] network within cells, which is crucial for [[cell division]]. This disruption leads to the inhibition of [[mitosis]] and induces [[apoptosis]] in rapidly dividing cancer cells. Additionally, it has anti-angiogenic properties, meaning it can inhibit the formation of new blood vessels that tumors need for growth and metastasis.
-==Potential therapeutic uses==
+The compound acts by disrupting the [[microtubule]] network within [[cancer cell]]s, leading to cell cycle arrest and [[apoptosis]]. It also inhibits [[angiogenesis]], the process by which new blood vessels form from pre-existing vessels, which is crucial for tumor growth and metastasis.
-The primary area of research for 2-methoxyestradiol disulfamate is in the treatment of various types of cancer, including [[breast cancer]], [[prostate cancer]], and [[ovarian cancer]]. Its ability to target both the cancer cells and the tumor vasculature makes it a promising candidate for cancer therapy.
-==Pharmacokinetics==
+== Therapeutic Potential ==
-The sulfamate modification in 2-methoxyestradiol disulfamate enhances its oral bioavailability compared to 2-methoxyestradiol. This modification allows for more effective systemic delivery and prolonged action in the body.
-==Research and development==
+-Methoxyestradiol disulfamate has shown promise in preclinical studies as an anti-cancer agent. It is particularly effective against [[breast cancer]], [[prostate cancer]], and [[ovarian cancer]]. Its ability to target multiple pathways involved in cancer progression makes it a candidate for further clinical development.
-Research on 2-methoxyestradiol disulfamate is ongoing, with studies focusing on its efficacy, safety, and potential as a therapeutic agent in oncology. Clinical trials are being conducted to better understand its role and effectiveness in cancer treatment.
+== Related Compounds ==
-==Related pages==
 * [[2-Methoxyestradiol]]
-* [[Estrogen]]
+* [[Estradiol]]
-* [[Cancer treatment]]
+* [[Sulfamate]]
-* [[Microtubule]]
+== Related Pages ==
+* [[Cancer therapy]]
+* [[Estrogen receptor]]
+* [[Microtubule inhibitors]]
-==Gallery==
+[[Category:Estrogens]]
+[[Category:Antineoplastic agents]]
+[[Category:Sulfamates]]
 <gallery>
-File:STX-140.svg|Chemical structure of 2-Methoxyestradiol disulfamate
+File:STX-140.svg|STX-140 chemical structure
 </gallery>
-[[Category:Estrogens]]
-[[Category:Antineoplastic drugs]]
-[[Category:Sulfamate esters]]