Kidney cancer: Difference between revisions

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{{Infobox medical condition
{{Infobox medical condition
| name = Kidney Cancer
| name = Kidney Cancer
| image = File:Clear cell renal cell carcinoma high mag cropped.jpg
| image =  
| caption = Micrograph of clear cell renal cell carcinoma, the most common type of kidney cancer
| caption =  
| field = [[Oncology]]
| field = Oncology
| symptoms = Blood in urine, flank pain, lump in the abdomen
| symptoms = Blood in urine, back pain, weight loss
| complications = Metastasis
| complications = Metastasis
| onset = Typically after age 50
| onset =  
| types = [[Renal cell carcinoma]], [[Transitional cell carcinoma]]
| duration =
| causes = [[Smoking]], obesity, hypertension, genetic factors
| types = Renal cell carcinoma, transitional cell carcinoma
| diagnosis = [[CT scan]], [[MRI]], [[Ultrasound]], [[Biopsy]]
| causes = Genetic mutations, smoking, obesity
| risks = Family history, hypertension
| diagnosis = Imaging, biopsy
| treatment = Surgery, targeted therapy, immunotherapy
| treatment = Surgery, targeted therapy, immunotherapy
| prognosis = Variable, depending on stage and type
| prognosis = Variable
| frequency = 400,000 new cases globally (2020)
| frequency =  
}}
}}


'''Kidney cancer''' is a type of cancer that starts in the cells of the kidneys. The most common type of kidney cancer in adults is [[renal cell carcinoma]] (RCC), which accounts for about 90% of cases. Other types include [[transitional cell carcinoma]] and [[Wilms' tumor]], which is more common in children.
'''Kidney cancer''' is a type of [[cancer]] that starts in the [[kidney]]s. The most common type of kidney cancer in adults is [[renal cell carcinoma]]. Other less common types include [[transitional cell carcinoma]] and [[Wilms' tumor]], which is more common in children.


==Types==
== Signs and Symptoms ==
The signs and symptoms of kidney cancer may include:
* [[Hematuria]] (blood in the urine)
* Persistent [[back pain]]
* Unexplained [[weight loss]]
* [[Fatigue]]
* [[Fever]]


===Renal Cell Carcinoma===
== Causes ==
Renal cell carcinoma is the most prevalent form of kidney cancer. It originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. There are several subtypes of RCC, including:
The exact cause of kidney cancer is not known, but several risk factors have been identified. These include:
* [[Smoking]]
* [[Obesity]]
* [[Hypertension]] (high blood pressure)
* Family history of kidney cancer
* Certain genetic conditions, such as [[von Hippel-Lindau disease]]


* '''Clear cell RCC''': The most common subtype, characterized by cells that appear very pale or clear under a microscope.
== Diagnosis ==
* '''Papillary RCC''': The second most common subtype, which forms small, finger-like projections.
Diagnosis of kidney cancer typically involves:
* '''Chromophobe RCC''': A less common subtype, with cells that are larger and have a distinct appearance.
* [[Imaging]] tests such as [[CT scan]] or [[MRI]]
* [[Biopsy]] to confirm the presence of cancer cells


[[File:Chromophobe renal cell carcinoma, eosinophilic variant - high mag.jpg|thumb|Micrograph of chromophobe renal cell carcinoma, eosinophilic variant]]
== Treatment ==
Treatment options for kidney cancer depend on the stage and type of cancer and may include:
* [[Surgery]] to remove the tumor or the entire kidney (nephrectomy)
* [[Targeted therapy]]
* [[Immunotherapy]]
* [[Radiation therapy]]


===Transitional Cell Carcinoma===
== Prognosis ==
Transitional cell carcinoma (TCC) of the kidney is less common and originates in the renal pelvis, the part of the kidney that collects urine before it moves to the bladder. TCC is more similar to bladder cancer than to RCC.
The prognosis for kidney cancer varies depending on the stage at diagnosis and the overall health of the patient. Early detection and treatment improve the chances of a favorable outcome.


===Wilms' Tumor===
== Prevention ==
Wilms' tumor is a rare kidney cancer that primarily affects children. It is usually diagnosed in children under the age of 5.
While there is no sure way to prevent kidney cancer, reducing risk factors such as quitting smoking, maintaining a healthy weight, and controlling blood pressure may help lower the risk.


==Symptoms==
== See Also ==
Common symptoms of kidney cancer include:
* [[Renal cell carcinoma]]
* Hematuria (blood in the urine)
* [[Transitional cell carcinoma]]
* Flank pain
* [[Wilms' tumor]]
* A palpable mass in the abdomen
* Unexplained weight loss
* Fatigue


==Diagnosis==
== References ==
Diagnosis of kidney cancer typically involves imaging studies such as [[CT scan]], [[MRI]], and [[ultrasound]]. A biopsy may be performed to confirm the diagnosis and determine the specific type of cancer.
{{Reflist}}


==Staging==
== External Links ==
Kidney cancer is staged based on the size of the tumor and the extent of its spread. The stages range from I to IV, with Stage I being localized and Stage IV indicating metastasis.
* [https://www.cancer.org/cancer/kidney-cancer.html American Cancer Society: Kidney Cancer]
 
* [https://www.cancer.gov/types/kidney National Cancer Institute: Kidney Cancer]
[[File:Diagram showing stage 1 kidney cancer CRUK 192.svg|thumb|Diagram showing stage 1 kidney cancer]]
 
==Treatment==
Treatment options for kidney cancer depend on the stage and type of cancer. They may include:
* '''Surgery''': The primary treatment for localized kidney cancer, which may involve partial or complete removal of the kidney (nephrectomy).
* '''Targeted therapy''': Drugs that target specific pathways involved in cancer cell growth.
* '''Immunotherapy''': Treatments that help the immune system fight cancer.
 
==Prognosis==
The prognosis for kidney cancer varies widely depending on the stage at diagnosis and the specific type of cancer. Early-stage kidney cancer has a better prognosis than advanced-stage disease.
 
==Also see==
* [[Bladder cancer]]
* [[Prostate cancer]]
* [[Liver cancer]]
* [[Oncology]]
 
{{Oncology}}


[[Category:Kidney cancer]]
[[Category:Kidney cancer]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Urologic cancers]]
[[Category:Urology]]
<gallery>
File:Clear cell renal cell carcinoma high mag cropped.jpg|Clear cell renal cell carcinoma
File:Papillary transitional cell carcinoma, renal pelvis, urinary obstruction,.jpg|Papillary transitional cell carcinoma
File:Chromophobe renal cell carcinoma, eosinophilic variant - high mag.jpg|Chromophobe renal cell carcinoma
File:Papillary renal cell carcinoma very high mag.jpg|Papillary renal cell carcinoma
File:Diagram showing stage 1 kidney cancer CRUK 192.svg|Stage 1 kidney cancer
File:Diagram showing stage 2 kidney cancer CRUK 209.svg|Stage 2 kidney cancer
File:Diagram showing stage 3 kidney cancer CRUK 222.svg|Stage 3 kidney cancer
File:Diagram showing stage 4 kidney cancer CRUK 231.svg|Stage 4 kidney cancer
</gallery>

Latest revision as of 00:56, 20 February 2025

Kidney Cancer
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Blood in urine, back pain, weight loss
Complications Metastasis
Onset
Duration
Types Renal cell carcinoma, transitional cell carcinoma
Causes Genetic mutations, smoking, obesity
Risks Family history, hypertension
Diagnosis Imaging, biopsy
Differential diagnosis N/A
Prevention N/A
Treatment Surgery, targeted therapy, immunotherapy
Medication N/A
Prognosis Variable
Frequency
Deaths N/A


Kidney cancer is a type of cancer that starts in the kidneys. The most common type of kidney cancer in adults is renal cell carcinoma. Other less common types include transitional cell carcinoma and Wilms' tumor, which is more common in children.

Signs and Symptoms[edit]

The signs and symptoms of kidney cancer may include:

Causes[edit]

The exact cause of kidney cancer is not known, but several risk factors have been identified. These include:

Diagnosis[edit]

Diagnosis of kidney cancer typically involves:

Treatment[edit]

Treatment options for kidney cancer depend on the stage and type of cancer and may include:

Prognosis[edit]

The prognosis for kidney cancer varies depending on the stage at diagnosis and the overall health of the patient. Early detection and treatment improve the chances of a favorable outcome.

Prevention[edit]

While there is no sure way to prevent kidney cancer, reducing risk factors such as quitting smoking, maintaining a healthy weight, and controlling blood pressure may help lower the risk.

See Also[edit]

References[edit]

<references group="" responsive="1"></references>


External Links[edit]