Fibroblast: Difference between revisions
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== Fibroblast == | |||
[[File:Fibroblastid_(BPAE).jpg|thumb|right|A fibroblast cell in culture.]] | |||
A '''fibroblast''' is a type of [[cell (biology)|cell]] that synthesizes the [[extracellular matrix]] and [[collagen]], the structural framework (stroma) for [[animal tissue]]s, and plays a critical role in [[wound healing]]. Fibroblasts are the most common cells of [[connective tissue]] in animals. | |||
== Structure == | |||
Fibroblasts are large, flat, elongated (spindle-shaped) cells possessing processes extending out from the ends of the cell body. They have a prominent [[nucleus (cell)|nucleus]] with one or two nucleoli and abundant [[endoplasmic reticulum|rough endoplasmic reticulum]]. | |||
== Function == | == Function == | ||
Fibroblasts are responsible for the production of the [[extracellular matrix]] and [[collagen]], which form the structural framework of tissues. They are also involved in the repair and maintenance of tissues. Fibroblasts play a crucial role in [[wound healing]] by migrating to the site of injury, where they proliferate and produce new extracellular matrix to replace the damaged tissue. | |||
== | == Development == | ||
== | Fibroblasts are derived from primitive [[mesenchyme]] and display the filament protein [[vimentin]], a marker of mesodermal origin. They can also arise from [[epithelial cells]] through a process known as [[epithelial-mesenchymal transition]] (EMT). | ||
== Role in Disease == | |||
Fibroblasts are involved in the pathogenesis of several diseases, including [[fibrosis]], where there is excessive deposition of extracellular matrix, and [[cancer]], where fibroblasts can contribute to the tumor microenvironment and promote tumor growth. | |||
== Related pages == | |||
* [[Connective tissue]] | |||
* [[Extracellular matrix]] | * [[Extracellular matrix]] | ||
* [[Collagen]] | * [[Collagen]] | ||
* [[Wound healing]] | * [[Wound healing]] | ||
* [[ | * [[Epithelial-mesenchymal transition]] | ||
[[Category:Cell biology]] | [[Category:Cell biology]] | ||
[[Category:Connective tissue cells]] | [[Category:Connective tissue cells]] | ||
Latest revision as of 11:47, 15 February 2025
Fibroblast[edit]
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A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.
Structure[edit]
Fibroblasts are large, flat, elongated (spindle-shaped) cells possessing processes extending out from the ends of the cell body. They have a prominent nucleus with one or two nucleoli and abundant rough endoplasmic reticulum.
Function[edit]
Fibroblasts are responsible for the production of the extracellular matrix and collagen, which form the structural framework of tissues. They are also involved in the repair and maintenance of tissues. Fibroblasts play a crucial role in wound healing by migrating to the site of injury, where they proliferate and produce new extracellular matrix to replace the damaged tissue.
Development[edit]
Fibroblasts are derived from primitive mesenchyme and display the filament protein vimentin, a marker of mesodermal origin. They can also arise from epithelial cells through a process known as epithelial-mesenchymal transition (EMT).
Role in Disease[edit]
Fibroblasts are involved in the pathogenesis of several diseases, including fibrosis, where there is excessive deposition of extracellular matrix, and cancer, where fibroblasts can contribute to the tumor microenvironment and promote tumor growth.
