TAAR5: Difference between revisions

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'''TAAR5''' (Trace Amine Associated Receptor 5) is a [[protein]] that is encoded in humans by the TAAR5 [[gene]]. It is a member of the [[Trace amine-associated receptor]] family, which is a group of G protein-coupled receptors that are predominantly expressed in the [[brain]] and are known to play a crucial role in [[neurological]] functions.
== TAAR5 ==
 
'''TAAR5''' (Trace Amine-Associated Receptor 5) is a [[G protein-coupled receptor]] (GPCR) that is part of the [[trace amine-associated receptor]] family. These receptors are known to be activated by trace amines, which are endogenous amines present in the [[nervous system]] at low concentrations.


== Function ==
== Function ==
TAAR5 is known to respond to the biogenic amine, [[3-iodothyronamine]], which is a naturally occurring amine that is derived from [[thyroid hormone]] metabolism. This interaction suggests that TAAR5 may play a role in the physiological functions that are regulated by the thyroid hormones.


== Clinical significance ==
TAAR5 is primarily expressed in the [[olfactory epithelium]] and is involved in the detection of volatile amines, which are compounds that can be found in [[body odor]] and [[decomposing organic matter]]. This receptor plays a role in the [[olfactory system]] by contributing to the perception of certain smells.
Alterations in the function of TAAR5 have been associated with a variety of neurological and psychiatric disorders, including [[schizophrenia]], [[bipolar disorder]], and [[depression]]. However, the exact role of TAAR5 in these conditions is not yet fully understood.
 
== Ligands ==
 
TAAR5 is activated by several ligands, including [[trimethylamine]], a compound that is associated with the characteristic odor of [[rotting fish]]. This receptor's ability to detect trimethylamine suggests a role in [[social communication]] and [[behavioral responses]] to environmental cues.


== See also ==
== Clinical Significance ==
 
Research into TAAR5 and other trace amine-associated receptors is ongoing, with potential implications for understanding [[neurological disorders]] and [[psychiatric conditions]]. The study of TAAR5 may provide insights into the mechanisms of [[olfactory dysfunction]] and its impact on [[human health]].
 
== See Also ==
* [[Trace amine-associated receptor]]
* [[Trace amine-associated receptor]]
* [[G protein-coupled receptor]]
* [[G protein-coupled receptor]]
* [[3-Iodothyronamine]]
* [[Olfactory system]]


== References ==
== References ==
<references />
<references/>


== External links ==
== External Links ==
* [https://www.ncbi.nlm.nih.gov/gene/134860 TAAR5] at the US National Library of Medicine Medical Subject Headings (MeSH)
* [https://www.wikimd.com/wiki/TAAR5 TAAR5 on WikiMD]


{{Receptor-stub}}
{{GPCR}}
[[Category:Receptors]]
[[Category:Olfactory system]]
[[Category:G protein-coupled receptors]]
[[Category:G protein-coupled receptors]]
[[Category:Human proteins]]
[[Category:TAAR5]]
{{G protein-coupled receptors}}
{{Human chromosome 6 gene stubs}}
{{stub}}

Latest revision as of 20:48, 30 December 2024

TAAR5[edit]

TAAR5 (Trace Amine-Associated Receptor 5) is a G protein-coupled receptor (GPCR) that is part of the trace amine-associated receptor family. These receptors are known to be activated by trace amines, which are endogenous amines present in the nervous system at low concentrations.

Function[edit]

TAAR5 is primarily expressed in the olfactory epithelium and is involved in the detection of volatile amines, which are compounds that can be found in body odor and decomposing organic matter. This receptor plays a role in the olfactory system by contributing to the perception of certain smells.

Ligands[edit]

TAAR5 is activated by several ligands, including trimethylamine, a compound that is associated with the characteristic odor of rotting fish. This receptor's ability to detect trimethylamine suggests a role in social communication and behavioral responses to environmental cues.

Clinical Significance[edit]

Research into TAAR5 and other trace amine-associated receptors is ongoing, with potential implications for understanding neurological disorders and psychiatric conditions. The study of TAAR5 may provide insights into the mechanisms of olfactory dysfunction and its impact on human health.

See Also[edit]

References[edit]

<references/>

External Links[edit]


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