Pyroglutamylated RFamide peptide receptor: Difference between revisions
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'''Pyroglutamylated RFamide | == Pyroglutamylated RFamide Peptide Receptor == | ||
The '''Pyroglutamylated RFamide Peptide Receptor''' (QRFPR) is a [[G protein-coupled receptor]] (GPCR) that is activated by the [[neuropeptide]] [[QRFP]]. This receptor is involved in various physiological processes, including the regulation of [[appetite]], [[metabolism]], and [[cardiovascular function]]. | |||
== Structure == | |||
QRFPR is a member of the [[G protein-coupled receptor]] family, which is characterized by seven transmembrane domains. These receptors are integral membrane proteins that transmit signals from extracellular ligands to intracellular [[G proteins]]. | |||
== Function == | == Function == | ||
== Clinical | The primary function of the QRFPR is to bind the [[neuropeptide]] [[QRFP]], also known as [[26RFa]], which is involved in the regulation of [[energy homeostasis]] and [[feeding behavior]]. Activation of QRFPR by QRFP leads to various downstream effects, including the modulation of [[hormone secretion]] and [[neuronal activity]]. | ||
Alterations in | |||
== Expression == | |||
QRFPR is expressed in several tissues, including the [[brain]], [[heart]], and [[adipose tissue]]. Its expression in the [[hypothalamus]] is particularly important for its role in regulating [[appetite]] and [[energy balance]]. | |||
== Clinical Significance == | |||
Alterations in QRFPR signaling have been implicated in [[obesity]] and [[metabolic disorders]]. Understanding the role of QRFPR in these conditions could lead to the development of new therapeutic strategies for managing [[obesity]] and related [[metabolic diseases]]. | |||
== See Also == | |||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[ | * [[Neuropeptide]] | ||
* [[ | * [[QRFP]] | ||
* [[ | * [[Energy homeostasis]] | ||
== References == | == References == | ||
== External | <references/> | ||
* [https://www. | |||
== External Links == | |||
* [https://www.wikimd.com/wiki/Pyroglutamylated_RFamide_peptide_receptor Pyroglutamylated RFamide Peptide Receptor on WikiMD] | |||
{{Receptor-stub}} | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category: | [[Category:Neuropeptides]] | ||
[[Category: | [[Category:Metabolism]] | ||
[[Category:Obesity]] | |||
Latest revision as of 17:00, 29 December 2024
Pyroglutamylated RFamide Peptide Receptor[edit]
The Pyroglutamylated RFamide Peptide Receptor (QRFPR) is a G protein-coupled receptor (GPCR) that is activated by the neuropeptide QRFP. This receptor is involved in various physiological processes, including the regulation of appetite, metabolism, and cardiovascular function.
Structure[edit]
QRFPR is a member of the G protein-coupled receptor family, which is characterized by seven transmembrane domains. These receptors are integral membrane proteins that transmit signals from extracellular ligands to intracellular G proteins.
Function[edit]
The primary function of the QRFPR is to bind the neuropeptide QRFP, also known as 26RFa, which is involved in the regulation of energy homeostasis and feeding behavior. Activation of QRFPR by QRFP leads to various downstream effects, including the modulation of hormone secretion and neuronal activity.
Expression[edit]
QRFPR is expressed in several tissues, including the brain, heart, and adipose tissue. Its expression in the hypothalamus is particularly important for its role in regulating appetite and energy balance.
Clinical Significance[edit]
Alterations in QRFPR signaling have been implicated in obesity and metabolic disorders. Understanding the role of QRFPR in these conditions could lead to the development of new therapeutic strategies for managing obesity and related metabolic diseases.
See Also[edit]
References[edit]
<references/>
External Links[edit]
