Zieve's syndrome

Zieve's Syndrome

Zieve's syndrome (pronounced: /ˈziːvz/), is a rare medical condition characterized by a triad of symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is typically associated with alcohol abuse.

Etymology

The syndrome is named after Dr. Leslie Zieve, who first described the condition in 1958.

Symptoms

The primary symptoms of Zieve's syndrome include:

• Hemolytic anemia: A condition in which red blood cells are destroyed and removed from the bloodstream before their normal lifespan is over.
• Cholestatic jaundice: A condition characterized by the interruption of the flow of bile, leading to the buildup of bilirubin in the blood and causing the skin and whites of the eyes to turn yellow.
• Hyperlipidemia: A condition characterized by abnormally elevated levels of any or all lipids or lipoproteins in the blood.

Causes

Zieve's syndrome is typically associated with chronic alcohol abuse. The exact mechanism of how alcohol abuse leads to the syndrome is not fully understood, but it is believed to involve the toxic effects of alcohol on the liver and red blood cells.

Diagnosis

Diagnosis of Zieve's syndrome is based on the presence of the characteristic triad of symptoms, along with a history of alcohol abuse. Laboratory tests may show elevated levels of bilirubin and lipids in the blood, and signs of hemolysis.

Treatment

Treatment of Zieve's syndrome primarily involves cessation of alcohol consumption. Additional treatments may be needed to manage the individual symptoms, such as blood transfusions for severe anemia, and medications to lower blood lipid levels.

Related Terms

• Alcohol abuse
• Hemolysis
• Jaundice
• Hyperlipidemia

External links

• Medical encyclopedia article on Zieve's syndrome
• Wikipedia's article - Zieve's syndrome

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