Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2 (pronunciation: noo-klee-er ree-sep-ter koh-ree-pres-er too), also known as NCOR2, is a protein that in humans is encoded by the NCOR2 gene.
Etymology
The term "nuclear receptor co-repressor 2" is derived from its function and location. "Nuclear" refers to the nucleus of a cell where this protein is often found. "Receptor" indicates that it is a type of protein that binds to specific molecules, and "co-repressor" signifies its role in inhibiting gene expression. The "2" denotes that it is the second of its kind to be discovered.
Function
The NCOR2 protein is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. It plays an integral role in regulating gene expression by forming complexes with other proteins and binding to DNA. This protein can interact with a variety of nuclear receptors, including thyroid hormone receptor and retinoic acid receptor, and it is involved in the repression of their target genes.
Related Terms
- Nuclear receptor: A class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
- Co-repressor: A protein that decreases gene expression by binding to a transcription factor which contains a DNA binding domain.
- Transcription: The first step of gene expression, where a particular segment of DNA is copied into RNA by the enzyme RNA polymerase.
- Gene: A unit of heredity which is transferred from a parent to offspring and is held to determine some characteristic of the offspring.
See Also
External links
- Medical encyclopedia article on Nuclear receptor co-repressor 2
- Wikipedia's article - Nuclear receptor co-repressor 2
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