Leukotrienes
Leukotrienes
Leukotrienes (/luːkoʊˈtraɪiːnz/), are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (Arachidonic Acid).
Etymology
The term "Leukotriene" is derived from "leuko-" which is a prefix from the Greek "leukos" meaning "white", and "triene" referring to the compound's three conjugated double bonds.
Function
Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. Leukotrienes are produced in the body from arachidonic acid by the enzyme 5-lipoxygenase (5-Lipoxygenase).
Types of Leukotrienes
There are four types of leukotrienes: Leukotriene A4, Leukotriene B4, Leukotriene C4, and Leukotriene D4. Each type has a different role in the body's immune response.
Leukotriene A4
Leukotriene A4 is an unstable intermediate in the biosynthesis of leukotrienes.
Leukotriene B4
Leukotriene B4 is involved in inflammation and works to recruit neutrophils to areas of tissue damage.
Leukotriene C4
Leukotriene C4 is involved in the contraction of smooth muscle tissues.
Leukotriene D4
Leukotriene D4 is involved in the contraction of smooth muscle tissues and increases vascular permeability.
Related Terms
External links
- Medical encyclopedia article on Leukotrienes
- Wikipedia's article - Leukotrienes
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