JUPITER trial
JUPITER trial
The JUPITER trial (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) is a clinical trial that was conducted to evaluate the effectiveness of rosuvastatin in preventing cardiovascular disease in individuals with normal cholesterol levels but elevated levels of C-reactive protein (CRP).
Pronunciation: /ˈdʒuːpɪtər traɪəl/
Etymology: The term "JUPITER trial" is an acronym derived from the full name of the study, "Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin."
Background
The JUPITER trial was initiated based on the hypothesis that individuals with elevated CRP levels, a marker of inflammation, may benefit from statin therapy even if their cholesterol levels are within the normal range. This hypothesis was based on previous studies suggesting a link between inflammation and cardiovascular disease.
Methodology
The trial involved over 17,000 participants from 26 countries who were randomly assigned to receive either rosuvastatin or a placebo. The primary endpoint of the trial was the occurrence of a major cardiovascular event, such as a heart attack or stroke.
Results
The results of the JUPITER trial, published in 2008, showed that rosuvastatin significantly reduced the incidence of major cardiovascular events in the study population. These findings led to a change in guidelines for the use of statins in primary prevention of cardiovascular disease.
Criticisms
Despite its significant findings, the JUPITER trial has been criticized for its methodology and interpretation of results. Some critics argue that the benefits of rosuvastatin were overstated and that the risks of statin therapy, such as diabetes and muscle problems, were not adequately addressed.
Related Terms
External links
- Medical encyclopedia article on JUPITER trial
- Wikipedia's article - JUPITER trial
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