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Information about Rosuvastatin
Rosuvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury.
Mechanism of action of Rosuvastatin
Rosuvastatin (roe soo" va stat' in) is a potent, orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase the major rate-limiting enzyme in cholesterol synthesis. Like other members of its class (the “statins”), rosuvastatin lowers total serum cholesterol and low density lipoprotein (LDL) concentrations, thereby reducing the risk of atherosclerosis and its complications – myocardial infarction and stroke.
FDA approval information for Rosuvastatin
Rosuvastatin was approved for use in the United States in 2003 and currently several million prescriptions are filled yearly. Rosuvastatin is indicated for treatment of hypercholesterolemia in persons at high risk for coronary, cerebrovascular and peripheral artery disease.
Dosage and administration for Rosuvastatin
Rosuvastatin is available in tablets of 5, 10, 20 and 40 mg generically and under the trade name Crestor. Rosuvastatin is one of the more potent statins available and is typically used in a comparably lower dose. The recommended dose in adults is 5 to 40 mg once daily, based upon tolerability and lipid levels.
Side effects of Rosuvastatin
Common side effects include muscle cramps, joint aches, headache and weakness.
Lipid lowering medications
- Niacin (Nicotinic Acid)