Interleukin 11
Interleukin 11
Interleukin 11 (pronounced /ˌɪntərˈluːkɪn ˈɛlɪvən/), often abbreviated as IL-11, is a protein that in humans is encoded by the IL11 gene.
Etymology
The term "Interleukin" originates from the prefix inter-, meaning "between", and the word leukin, derived from leukocytes, which are white blood cells. The number "11" signifies that it was the 11th interleukin to be discovered.
Function
IL-11 is a member of the interleukin family, a group of cytokines expressed by leukocytes. IL-11 is produced by stromal cells in the bone marrow and plays a crucial role in controlling the growth of hematopoietic stem cells and other cells of the immune system.
Clinical Significance
IL-11 has been used therapeutically in the treatment of thrombocytopenia, a condition characterized by low platelet count, often associated with chemotherapy and radiation therapy in cancer patients. It is also being studied for its potential role in inflammatory diseases such as rheumatoid arthritis and Crohn's disease.
Related Terms
- Cytokines
- Leukocytes
- Stromal cells
- Bone marrow
- Hematopoietic stem cells
- Thrombocytopenia
- Chemotherapy
- Radiation therapy
- Rheumatoid arthritis
- Crohn's disease
External links
- Medical encyclopedia article on Interleukin 11
- Wikipedia's article - Interleukin 11
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