Hepatosplenic T-cell lymphoma

Hepatosplenic T-cell Lymphoma

Hepatosplenic T-cell lymphoma (pronunciation: hep-a-toe-splee-nik tee-cell lim-fo-ma) is a rare and aggressive subtype of Peripheral T-cell lymphoma that primarily affects the liver and spleen.

Etymology

The term "Hepatosplenic" is derived from the Greek words "hepar" meaning liver and "splen" meaning spleen. "T-cell" refers to the type of lymphocyte that the cancer originates from, and "lymphoma" is a general term for cancers that develop in the lymphatic system.

Overview

Hepatosplenic T-cell lymphoma is characterized by the abnormal proliferation of T-cells, a type of white blood cell, in the liver and spleen. This lymphoma subtype is often associated with a poor prognosis due to its aggressive nature and resistance to standard chemotherapy regimens.

Symptoms

Common symptoms of Hepatosplenic T-cell lymphoma include fever, fatigue, weight loss, and enlargement of the liver and spleen (hepatosplenomegaly).

Diagnosis

Diagnosis is typically made through a combination of physical examination, blood tests, imaging studies, and biopsy of the affected organ(s). The definitive diagnosis is made by identifying the characteristic immunophenotype of the malignant T-cells.

Treatment

Treatment options for Hepatosplenic T-cell lymphoma are limited due to its resistance to standard chemotherapy regimens. Current treatment strategies often involve a combination of chemotherapy, immunotherapy, and in some cases, stem cell transplantation.

Related Terms

External links

Medical encyclopedia article on Hepatosplenic T-cell lymphoma
Wikipedia's article - Hepatosplenic T-cell lymphoma

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