Hemicholinium-3
Hemicholinium-3
Hemicholinium-3 (pronunciation: he-mi-ko-li-ni-um-3), often abbreviated as HC-3, is a potent drug known for its ability to inhibit the high-affinity choline transporter (CHT). The etymology of the term is derived from the Greek words 'hemi' meaning half, and 'cholinium' referring to its action on choline, a vital neurotransmitter.
Mechanism of Action
Hemicholinium-3 acts by blocking the choline transporter, thereby inhibiting the reuptake of choline into the presynaptic neuron. This results in a decrease in the synthesis of acetylcholine, a key neurotransmitter involved in muscle contraction and other physiological processes.
Clinical Significance
Due to its ability to inhibit acetylcholine synthesis, Hemicholinium-3 has been used in research to study various neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. However, its use in humans is limited due to its high toxicity.
Related Terms
- Choline: A vital neurotransmitter that is blocked by Hemicholinium-3.
- Acetylcholine: A neurotransmitter whose synthesis is inhibited by Hemicholinium-3.
- Choline transporter: A protein that is blocked by Hemicholinium-3, leading to decreased acetylcholine synthesis.
- Neurotransmitter: A chemical substance that transmits nerve impulses across a synapse.
External links
- Medical encyclopedia article on Hemicholinium-3
- Wikipedia's article - Hemicholinium-3
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