Familial Mediterranean Fever
Familial Mediterranean Fever (pronunciation: fa-MIL-ee-al MED-i-ter-RAY-nee-an FEE-ver, abbreviated as FMF) is a genetic disorder that typically affects individuals of Mediterranean descent, although it can occur in any ethnic group.
Etymology
The term "Familial Mediterranean Fever" is derived from the fact that the disorder is often inherited (familial) and is most common among people of Mediterranean descent (Mediterranean). The term "fever" refers to the recurrent episodes of fever that are a key feature of the disorder.
Symptoms
The primary symptoms of Familial Mediterranean Fever are recurrent episodes of fever and painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by a rash. The severity and duration of the episodes can vary greatly from person to person.
Causes
Familial Mediterranean Fever is caused by mutations in the MEFV gene, which encodes a protein called pyrin. Pyrin plays a crucial role in the body's immune response, helping to regulate inflammation. Mutations in the MEFV gene lead to uncontrolled inflammation, resulting in the symptoms of Familial Mediterranean Fever.
Diagnosis
Diagnosis of Familial Mediterranean Fever is typically based on the characteristic symptoms and a family history of the disorder. Genetic testing can confirm the diagnosis.
Treatment
Treatment for Familial Mediterranean Fever primarily involves managing the symptoms. This can include the use of anti-inflammatory drugs and other medications to reduce inflammation and prevent complications.
Related Terms
External links
- Medical encyclopedia article on Familial Mediterranean Fever
- Wikipedia's article - Familial Mediterranean Fever
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