Enclomifene
Enclomifene (pronounced en-KLO-mi-feen) is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. It is a isomer of clomifene and is used in the treatment of secondary hypogonadism in males.
Etymology
The term "Enclomifene" is derived from the words "enclomiphene citrate," which is the international nonproprietary name for the drug. The "en" prefix refers to the enclomiphene isomer of clomifene.
Pharmacology
Enclomifene is a selective estrogen receptor modulator (SERM). It works by inhibiting the negative feedback of estrogen at the hypothalamus. This results in an increase in the secretion of gonadotropin-releasing hormone (GnRH) which then stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then stimulate the testes to produce testosterone and sperm.
Clinical Use
Enclomifene is used in the treatment of secondary hypogonadism in overweight men wishing to restore normal testicular function. It is also being investigated for use in the treatment of men with low testosterone levels due to aging.
Related Terms
- Clomifene
- Estrogen receptor antagonist
- Gonadotropin
- Testosterone
- Hypogonadism
- Isomer
- Hypothalamus
- Gonadotropin-releasing hormone
- Luteinizing hormone
- Follicle-stimulating hormone
External links
- Medical encyclopedia article on Enclomifene
- Wikipedia's article - Enclomifene
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