Elevated alkaline phosphatase

Elevated Alkaline Phosphatase

Elevated alkaline phosphatase (pronounced: al-kah-line fos-fa-tase) is a medical condition characterized by higher than normal levels of the enzyme alkaline phosphatase (ALP) in the blood.

Etymology

The term "alkaline phosphatase" is derived from its optimal pH being in the alkaline range. The term "phosphatase" refers to its ability to remove phosphate groups from molecules, including nucleotides, proteins, and alkaloids.

Overview

Alkaline phosphatase is an enzyme found in several tissues throughout the body, with the highest concentrations found in the liver, bile ducts, and bone. An elevated level of this enzyme in the blood is often associated with active bone formation occurring as if often seen in diseases affecting the bone or liver diseases such as hepatitis or biliary obstruction.

Causes

Elevated alkaline phosphatase levels can be caused by a variety of conditions, including liver disease, bone disorders, or certain cancers. Other causes can include certain medications, alcohol abuse, or pregnancy.

Symptoms

Symptoms of elevated alkaline phosphatase can vary depending on the underlying cause. They may include fatigue, weakness, loss of appetite, nausea, and jaundice.

Diagnosis

Diagnosis of elevated alkaline phosphatase is typically made through a blood test. Further diagnostic tests may be required to determine the underlying cause of the elevated levels.

Treatment

Treatment for elevated alkaline phosphatase typically involves addressing the underlying cause. This may involve medication, lifestyle changes, or in some cases, surgery.

Related Terms

• Liver disease
• Bone disorders
• Hepatitis
• Biliary obstruction
• Jaundice

External links

• Medical encyclopedia article on Elevated alkaline phosphatase
• Wikipedia's article - Elevated alkaline phosphatase

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