Deleterious mutation
Deleterious Mutation
A Deleterious Mutation (pronunciation: /dɪˈlɪtərɪəs mjuːˈteɪʃən/) is a type of genetic mutation that negatively impacts the fitness of an organism.
Etymology
The term "Deleterious Mutation" is derived from the Latin word "deleterius", meaning "destructive", and the Latin word "mutatio", meaning "a changing".
Definition
A Deleterious Mutation is a change in the DNA sequence of an organism's genome that is harmful to the organism. This can occur in any part of the genome, including both the coding and non-coding regions.
Types of Deleterious Mutations
There are several types of Deleterious Mutations, including:
- Missense Mutations: These mutations result in a change in one amino acid in a protein, which can alter the function of the protein.
- Nonsense Mutations: These mutations result in a premature stop codon, which can lead to a truncated, non-functional protein.
- Frameshift Mutations: These mutations result from the insertion or deletion of a number of nucleotides that is not a multiple of three, which can shift the reading frame of the gene and result in a completely different protein sequence.
Impact of Deleterious Mutations
Deleterious Mutations can have a wide range of effects on an organism, depending on the specific mutation and the gene in which it occurs. Some mutations may have little to no effect on the organism, while others can cause serious diseases or conditions, such as cancer, cystic fibrosis, and sickle cell disease.
Related Terms
External links
- Medical encyclopedia article on Deleterious mutation
- Wikipedia's article - Deleterious mutation
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski