Contraction band necrosis
Contraction Band Necrosis
Contraction band necrosis (pronunciation: /kənˈtrakʃ(ə)n band nɪˈkrəʊsɪs/) is a form of myocardial necrosis characterized by hypercontracted sarcomeres and disrupted myofibrils.
Etymology
The term "contraction band necrosis" is derived from the English words "contraction" (from Latin contractio, from contrahere 'draw together'), "band" (from Old Norse band), and "necrosis" (from Greek nekrosis, a killing, from nekros 'dead').
Definition
Contraction band necrosis is a type of cell death that occurs in the heart muscle (myocardium) due to reperfusion injury. It is characterized by the presence of contraction bands, which are hypercontracted sarcomeres, in the myocytes. These bands are formed due to an excessive influx of calcium ions into the cells, leading to hypercontraction of the sarcomeres and subsequent cell death.
Related Terms
- Myocardial infarction: A condition in which a part of the heart muscle dies due to lack of blood supply.
- Reperfusion injury: Damage to tissues caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen.
- Calcium overload: A condition characterized by an excessive amount of calcium in the cells, which can lead to cell death.
- Myocytes: Muscle cells, specifically heart muscle cells in this context.
- Sarcomeres: The basic unit of muscle tissue; in this context, it refers to those of the heart muscle cells.
See Also
External links
- Medical encyclopedia article on Contraction band necrosis
- Wikipedia's article - Contraction band necrosis
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