Beta-2 adrenergic receptor

The Beta-2 adrenergic receptor (pronounced as "beta two ad-ren-er-gic re-cep-tor"), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with epinephrine, a hormone and neurotransmitter. The etymology of the term originates from the Greek words "adrenes" meaning 'near the kidney' and "ergon" meaning 'work'.

Function

The Beta-2 adrenergic receptor's primary function is to mediate the catecholamine-induced activation of adenylyl cyclase through the action of G proteins. This results in an increase in cyclic AMP, leading to the activation of protein kinase A, which in turn mediates many of the cellular responses to catecholamines.

Clinical significance

Beta-2 adrenergic receptors have clinical significance in their role in the treatment of asthma. Medications such as albuterol and salmeterol are beta-2 agonists that relax the muscles in the airways and increase airflow to the lungs.

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Beta-2 adrenergic receptor

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