Anti-estrogen
Anti-estrogen
Anti-estrogen (pronunciation: an-tee-es-tro-jen) refers to a group of drugs that inhibit the effects of estrogen, a hormone that promotes the growth of some types of cancer cells.
Etymology
The term "anti-estrogen" is derived from the Greek words "anti" meaning against, and "oistros" meaning passion or desire, which later evolved into the modern term "estrogen".
Types of Anti-estrogen Drugs
There are two main types of anti-estrogen drugs: Selective Estrogen Receptor Modulators (SERMs) and Aromatase Inhibitors (AIs).
- Selective Estrogen Receptor Modulators (SERMs): These drugs bind to estrogen receptors in the body, blocking estrogen from binding. Examples include Tamoxifen and Raloxifene.
- Aromatase Inhibitors (AIs): These drugs work by blocking the enzyme aromatase, which the body uses to make estrogen. Examples include Anastrozole, Letrozole, and Exemestane.
Uses
Anti-estrogen drugs are primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. They can also be used to treat infertility in women, as they can stimulate ovulation.
Side Effects
Common side effects of anti-estrogen drugs can include hot flashes, vaginal dryness or discharge, and mood changes. More serious side effects can include blood clots, stroke, and endometrial cancer.
Related Terms
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