Vadadustat
Vadadustat
Vadadustat (pronounced vah-duh-DUH-stat) is a pharmaceutical drug used for the treatment of anemia associated with chronic kidney disease (CKD). It is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that stimulates the body's natural response to low oxygen levels in the blood, leading to the increased production of red blood cells.
Etymology
The name "Vadadustat" is derived from the Latin words "vada" meaning "go" and "dustat" meaning "given". This could be interpreted as "given to go", possibly referring to the drug's function of helping red blood cells to carry oxygen more efficiently.
Usage
Vadadustat is used to treat anemia in patients with chronic kidney disease. It works by inhibiting the enzyme prolyl hydroxylase, which is involved in the degradation of hypoxia-inducible factors (HIFs). By inhibiting this enzyme, HIFs are stabilized, leading to increased production of erythropoietin, a hormone that stimulates the production of red blood cells.
Related Terms
- Anemia: A condition characterized by a deficiency of red cells or of haemoglobin in the blood, resulting in pallor and weariness.
- Chronic Kidney Disease (CKD): A long-term condition where the kidneys do not work effectively.
- Hypoxia-inducible factor (HIF): A transcription factor that responds to decreases in available oxygen in the cellular environment.
- Prolyl hydroxylase: An enzyme that plays a role in the body's response to low levels of oxygen.
- Erythropoietin (EPO): A hormone produced by the kidney that promotes the formation of red blood cells in the bone marrow.
External links
- Medical encyclopedia article on Vadadustat
- Wikipedia's article - Vadadustat
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