VIR-576

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VIR-576

VIR-576 is a peptide-based entry inhibitor that targets the HIV-1 virus, specifically designed to prevent the virus from entering host cells. It is derived from the naturally occurring peptide VIRIP, which is found in human blood.

Mechanism of Action

VIR-576 functions by binding to the gp41 subunit of the HIV envelope glycoprotein. This binding inhibits the conformational changes necessary for the fusion of the viral and cellular membranes, thereby blocking the entry of the virus into the host cell. The peptide mimics a region of the gp41 protein, interfering with the fusion process.

3D structure of VIR-576

Development and Research

The development of VIR-576 was based on the discovery of the VIRIP peptide, which was identified as a natural inhibitor of HIV-1. Researchers modified VIRIP to enhance its antiviral activity, resulting in the creation of VIR-576. Clinical trials have demonstrated its potential efficacy in reducing viral load in patients with HIV.

Structure of VIRIP

Clinical Trials

Initial clinical trials of VIR-576 have shown promising results, with a significant reduction in viral load observed in patients. The trials focused on the safety and efficacy of the peptide, and further studies are ongoing to optimize its use in combination with other antiretroviral therapies.

Structure of VIR-576

Advantages and Challenges

One of the main advantages of VIR-576 is its novel mechanism of action, which differs from other antiretroviral drugs. This makes it a valuable addition to the existing arsenal of HIV treatments, particularly for patients with drug-resistant strains of the virus. However, challenges remain in terms of delivery and stability of the peptide in the human body.

Secondary structure of VIRIP

Related Pages

References



Secondary structure of VIR-576

External Links

  • VIR-576 3D Structure

  • Estructura VIRIP

  • Estructura VIR-576

  • VIRIP Secondary Structure

  • VIR-576 Secondary Structure

  • HIV Attachment

  • HIV-1 MARAV

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Contributors: Prab R. Tumpati, MD