UGT1A10

Ideogram human chromosome 2

UGT1A10

UGT1A10 is a gene that encodes an enzyme known as UDP-glucuronosyltransferase 1-10. This enzyme is primarily involved in the process of glucuronidation, which is a phase II metabolism reaction that facilitates the elimination of various endogenous and exogenous compounds from the body.

Function

The UGT1A10 enzyme is responsible for transferring glucuronic acid to a substrate molecule, thereby increasing its solubility in water and facilitating its excretion from the body. This process plays a crucial role in the metabolism of a wide range of compounds, including drugs, toxins, and hormones.

Clinical Significance

Mutations in the UGT1A10 gene can lead to alterations in enzyme activity, which may impact an individual's ability to metabolize certain substances. Variations in UGT1A10 activity have been associated with differences in drug response and susceptibility to certain diseases.

Regulation

The expression of the UGT1A10 gene is tightly regulated by various factors, including genetic, environmental, and hormonal influences. Understanding the mechanisms that control UGT1A10 expression is essential for predicting drug metabolism and potential drug-drug interactions.

References

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