Estradiol/medroxyprogesterone acetate

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Estradiol/medroxyprogesterone acetate is a combination form of hormone replacement therapy (HRT) that contains estradiol, a form of the main female sex hormone estrogen, and medroxyprogesterone acetate (MPA), a derivative of progesterone. It is used to treat symptoms of menopause such as hot flashes and vaginal dryness, itching, and burning.

Etymology

The term "estradiol" is derived from estrus (period of fertility for female mammals) + diol (a chemical term indicating a certain type of structure involving two alcohol groups). "Medroxyprogesterone acetate" is named for its components: medroxy indicating the presence of a methoxy group, progesterone being the hormone it is derived from, and acetate indicating the presence of an acetyl group.

Pharmacology

Estradiol and medroxyprogesterone acetate work together to alleviate menopausal symptoms by replenishing the declining levels of these hormones in the body. Estradiol, as a form of estrogen, helps to regulate the menstrual cycle and is also responsible for the development of female secondary sexual characteristics. Medroxyprogesterone acetate, on the other hand, is a progestin, or synthetic form of progesterone, which helps to regulate the uterus lining.

Usage

This medication is usually taken orally as directed by a healthcare professional. The dosage is based on the patient's medical condition and response to treatment. It is important to take this medication regularly to get the most benefit from it.

Side Effects

Possible side effects of estradiol/medroxyprogesterone acetate include nausea, bloating, breast tenderness, headache, or weight changes. If any of these effects persist or worsen, patients are advised to tell their doctor or pharmacist promptly.

See Also

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Estradiol/medroxyprogesterone acetate

  • Estradiol

  • Medroxyprogesterone acetate

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Contributors: Prab R. Tumpati, MD