Tregalizumab
Tregalizumab is a monoclonal antibody designed for the treatment of autoimmune diseases. It is a humanized antibody that binds to the CD4 receptor on certain T cells. It was developed by Biotest.
Mechanism of action
Tregalizumab binds to a specific site on the CD4 receptor that is only exposed on regulatory T cells (Tregs). This binding enhances the suppressive function of Tregs, which in turn reduces the activity of effector T cells, the cells that cause damage in autoimmune diseases.
Clinical trials
Tregalizumab has been tested in several clinical trials. In a phase II trial for rheumatoid arthritis, it showed a trend towards efficacy but did not meet its primary endpoint. Further development for this indication was therefore halted. However, it is still being investigated for other autoimmune diseases.
References
See also
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