Topical hydrocortisone

Topical Hydrocortisone

Chemical structure of hydrocortisone

Annotated chemical structure of hydrocortisone

Topical hydrocortisone is a corticosteroid medication used to treat a variety of skin conditions. It is applied directly to the skin to reduce inflammation, swelling, and irritation. Hydrocortisone is a synthetic form of cortisol, a hormone naturally produced by the adrenal gland.

Uses

Topical hydrocortisone is commonly used to treat conditions such as eczema, psoriasis, dermatitis, allergic reactions, and rashes. It works by suppressing the immune response and reducing inflammation in the affected area.

Mechanism of Action

Hydrocortisone acts by binding to glucocorticoid receptors in the skin, leading to a decrease in the production of inflammatory mediators. This results in reduced redness, swelling, and itching. The drug mimics the action of cortisol, which is involved in the body's response to stress and inflammation.

Side Effects

Overview of glucocorticoid-associated side effects

While topical hydrocortisone is generally safe when used as directed, it can cause side effects, especially with prolonged use. Common side effects include skin thinning, stretch marks, and increased susceptibility to skin infections. In rare cases, systemic absorption can lead to more serious effects such as Cushing's syndrome.

Application

Topical hydrocortisone is available in various forms, including creams, ointments, and lotions. It is typically applied to the affected area one to four times daily, depending on the severity of the condition and the strength of the preparation.

Tube of hydrocortisone cream

Topical hydrocortisone cream with neomycin

Precautions

Patients are advised to use topical hydrocortisone only as prescribed by a healthcare provider. It should not be used on broken or infected skin unless directed by a doctor. Long-term use should be avoided to prevent potential side effects.

Related Pages

• Corticosteroid
• Eczema
• Psoriasis
• Dermatitis

References

• 
  Chemical structure of cortisol
• 
  Overview of glucocorticoid-associated side effects
• 
  Annotated chemical structure of hydrocortisone
• 
  Tube of hydrocortisone cream
• 
  Topical hydrocortisone cream with neomycin