Thiophanate-methyl
Overview
Thiophanate-methyl is a systemic fungicide used in agriculture to control a wide range of fungal diseases. It belongs to the class of benzimidazole fungicides and is known for its broad-spectrum activity against various plant pathogens.
Chemical Properties
Thiophanate-methyl is a thiophanate compound, characterized by its chemical structure that includes a benzimidazole moiety. It is a white crystalline solid with a molecular formula of C12H14N4O4S2. The compound is relatively stable under normal conditions but can degrade into other active metabolites, such as carbendazim, which also possess fungicidal properties.
Mode of Action
Thiophanate-methyl acts by inhibiting the synthesis of tubulin, a protein essential for the formation of microtubules in fungal cells. This disruption of microtubule formation interferes with cell division, ultimately leading to the death of the fungal organism. Its systemic nature allows it to be absorbed by plant tissues and translocated to various parts of the plant, providing protective and curative effects.
Applications
Thiophanate-methyl is widely used in the agricultural industry to protect crops such as fruits, vegetables, ornamentals, and turf from fungal infections. It is effective against diseases like powdery mildew, leaf spot, blight, and root rot. The fungicide can be applied as a foliar spray, soil drench, or seed treatment, depending on the specific crop and disease.
Safety and Environmental Impact
While thiophanate-methyl is considered effective in controlling fungal diseases, it is important to use it responsibly to minimize potential risks to human health and the environment. Users should follow recommended application rates and safety guidelines to reduce exposure. The compound can persist in the environment and may pose risks to non-target organisms, including aquatic life, if not managed properly.
Regulatory Status
Thiophanate-methyl is registered for use in many countries, subject to regulatory approvals and restrictions. It is important for users to comply with local regulations and guidelines when using this fungicide to ensure safe and effective application.
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Contributors: Prab R. Tumpati, MD