TKM-Ebola

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TKM-Ebola

TKM-Ebola (/tiːkeɪɛmːiːboʊlə/), also known as TKM-130803, is an experimental treatment for the Ebola virus disease. It is developed by Tekmira Pharmaceuticals, a Canadian biopharmaceutical company.

Etymology

The name TKM-Ebola is derived from the initials of the company that developed it, Tekmira Kinetic Medicine, and the disease it is designed to treat, Ebola.

Description

TKM-Ebola is a type of RNA interference (RNAi) therapeutic, which works by inhibiting the replication of the Ebola virus within the host's cells. It is composed of small interfering RNAs (siRNAs) that are encapsulated in lipid nanoparticles.

Development and Use

The development of TKM-Ebola began in the early 2000s, in response to the increasing global threat of the Ebola virus. It was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) in 2014, during the West Africa Ebola outbreak.

Despite its experimental status, TKM-Ebola has been used under emergency protocols to treat a small number of patients with Ebola virus disease.

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