TAS2R50

TAS2R50

Symbol	TAS2R50
HGNC ID	14856
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	12p13.2
Locus supplementary data	–

TAS2R50 is a member of the TAS2R family of taste receptors, specifically involved in the perception of bitter taste. These receptors are G protein-coupled receptors (GPCRs) that are expressed in taste buds and are responsible for detecting bitter compounds.

Function

TAS2R50, like other bitter taste receptors, plays a crucial role in the detection of potentially harmful substances, as many bitter compounds are toxic. The activation of TAS2R50 by bitter substances triggers a signal transduction pathway that results in the perception of bitterness, which can lead to aversive behavior and avoidance of the bitter substance.

Genetic Variability

The TAS2R50 gene exhibits significant genetic variation among different populations, which can influence individual differences in taste perception. Variants of TAS2R50 have been associated with differences in sensitivity to certain bitter compounds, which may affect dietary preferences and nutrition.

Clinical Significance

Research has suggested that variations in the TAS2R50 gene may be linked to cardiovascular disease risk. Some studies have found associations between TAS2R50 polymorphisms and atherosclerosis, although the mechanisms are not fully understood. Further research is needed to elucidate the role of TAS2R50 in cardiovascular health.

See Also

• Taste receptor
• Bitter taste receptor
• G protein-coupled receptor

External Links

• TAS2R50 on WikiMD
• TAS2R50 Gene - NCBI