Synthetic rescue
Synthetic rescue
Synthetic rescue (pronunciation: /ˈsɪnθɛtɪk 'rɛskjuː/) is a term used in genetics and molecular biology to describe a situation where the deleterious effects of a mutation in a gene are compensated or 'rescued' by a second mutation in a different gene. The concept of synthetic rescue is important in understanding the complex interactions between genes and their role in various biological processes and diseases.
Etymology
The term 'synthetic rescue' is derived from the words 'synthetic', which comes from the Greek word 'synthetos' meaning 'put together', and 'rescue', which originates from the Old French 'rescourre' meaning 'to protect'. In the context of genetics, it refers to the 'protection' or 'rescue' of a cell or organism from the harmful effects of a mutation through the 'synthesis' or interaction of another gene.
Related Terms
- Synthetic lethality: A related concept where two non-lethal mutations become lethal when combined in the same cell or organism.
- Epistasis: A phenomenon where the effect of one gene is dependent on the presence of one or more 'modifier genes'.
- Genetic interaction: The phenomenon where the effect of a gene mutation is modified by the mutation in another gene.
- Mutation: A change in the DNA sequence that can lead to changes in the function of a gene.
- Gene: A unit of heredity which is transferred from a parent to offspring and is held to determine some characteristic of the offspring.
See Also
External links
- Medical encyclopedia article on Synthetic rescue
- Wikipedia's article - Synthetic rescue
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