Synthetic lethality
| Synthetic lethality | |
|---|---|
| Term | Synthetic lethality |
| Short definition | synthetic lethality - (pronounced) (sin-THEH-tik lee-THA-luh-tee) Describes a situation in which mutations (changes) in two genes together lead to cell death, but mutation in either gene alone does not. Cancer cells that have only one mutated gene in a given pair of genes may depend on the normal partner gene for survival. |
| Type | Cancer terms |
| Specialty | Oncology |
| Language | English |
| Source | NCI |
| Comments | |
synthetic lethality - (pronounced) (sin-THEH-tik lee-THA-luh-tee) Describes a situation in which mutations (changes) in two genes together lead to cell death, but mutation in either gene alone does not. Cancer cells that have only one mutated gene in a given pair of genes may depend on the normal partner gene for survival. Disrupting the normal partner gene's function can lead to the death of cancer cells. Studying synthetic lethality can help researchers learn more about how genes work and develop new drugs to treat cancer
External links
- Medical encyclopedia article on Synthetic lethality
- Wikipedia's article - Synthetic lethality
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