Surinabant

Surinabant

Surinabant is a selective antagonist of the CB1 receptor and was researched as a potential treatment for nicotine addiction and obesity. It was developed by Sanofi-Aventis but its development was discontinued in 2011.

History

Sanofi-Aventis, a global pharmaceutical company, developed Surinabant with the aim of treating conditions such as nicotine addiction and obesity. The development of Surinabant was part of a wider trend in the pharmaceutical industry to explore the therapeutic potential of cannabinoid receptor antagonists. However, the development of Surinabant was discontinued in 2011.

Pharmacology

Surinabant is a selective antagonist of the CB1 receptor, which is one of the two main receptors in the endocannabinoid system. The CB1 receptor is primarily located in the brain and is involved in a variety of physiological processes, including appetite regulation and the addictive properties of nicotine. By blocking the CB1 receptor, Surinabant was intended to reduce appetite and decrease the rewarding effects of nicotine.

Clinical Trials

Surinabant underwent several clinical trials to assess its safety and efficacy. However, the results of these trials were mixed. Some studies suggested that Surinabant could reduce the rewarding effects of nicotine and decrease appetite. However, other studies found that Surinabant had little effect on appetite and did not significantly reduce nicotine cravings. In addition, some participants in the trials reported experiencing adverse side effects, including depression and anxiety.

Discontinuation

The development of Surinabant was discontinued in 2011. This decision was made in light of the mixed results from the clinical trials and the reported side effects. The discontinuation of Surinabant was part of a wider trend in the pharmaceutical industry, with several other companies also discontinuing their development of CB1 receptor antagonists around the same time.

See Also

• Cannabinoid receptor antagonist
• CB1 receptor
• Sanofi-Aventis
• Nicotine addiction
• Obesity

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