Subventricular zone
Subventricular Zone
The Subventricular Zone (SVZ), pronounced as /sʌbˌvɛnˈtrɪkjʊlər zoʊn/, is a region in the brain where neurogenesis, the process of generating new neurons, occurs. The term "subventricular" is derived from the Latin words "sub" meaning "under" and "ventriculus" meaning "small cavity or chamber", referring to its location beneath the ventricles of the brain.
Structure
The Subventricular Zone is located in the walls of the lateral ventricles. It is composed of four layers: the ependymal layer, the subependymal layer, the intermediate zone, and the ribbon. Each of these layers has a distinct population of cells and contributes to the overall function of the SVZ.
Function
The primary function of the Subventricular Zone is to serve as a source of neural stem cells in the process of neurogenesis. These neural stem cells can differentiate into various types of brain cells, including neurons, astrocytes, and oligodendrocytes. The SVZ is one of the few areas in the adult brain where neurogenesis is known to occur.
Clinical Significance
Alterations in the Subventricular Zone have been associated with various neurological disorders, including Parkinson's disease, Alzheimer's disease, and stroke. Research is ongoing to understand the potential therapeutic applications of SVZ neurogenesis in these conditions.
See Also
References
External links
- Medical encyclopedia article on Subventricular zone
- Wikipedia's article - Subventricular zone
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