Steroidal aromatase inhibitor
Steroidal aromatase inhibitor is a type of aromatase inhibitor that is structurally similar to the steroid substrate androstenedione. It is used in the treatment of estrogen-dependent conditions such as breast cancer.
Mechanism of Action[edit]
Steroidal aromatase inhibitors work by binding to the aromatase enzyme, which is responsible for the conversion of androgens to estrogens in the body. By inhibiting this enzyme, these drugs reduce the levels of estrogen in the body, which can slow the growth of estrogen-dependent tumors.
Examples[edit]
Examples of steroidal aromatase inhibitors include exemestane and formestane. These drugs are often used in the treatment of postmenopausal women with hormone receptor-positive breast cancer.
Side Effects[edit]
Common side effects of steroidal aromatase inhibitors include hot flashes, joint pain, and fatigue. More serious side effects can include osteoporosis, heart disease, and stroke.
Pharmacokinetics[edit]
Steroidal aromatase inhibitors are typically administered orally. They are metabolized in the liver and excreted in the urine.
See Also[edit]
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