Sjögren syndrome antigen B
Sjögren syndrome antigen B (also known as SSB or La) is a protein that in humans is encoded by the SSB gene. SSB is an autoantigen in Sjögren syndrome and systemic lupus erythematosus.
Function
The SSB protein is involved in the processing of RNA molecules and the regulation of RNA polymerase III. It binds to the 3' UTR region of newly synthesized RNA polymerase III transcripts, preventing these transcripts from being degraded.
Clinical significance
SSB is an autoantigen in Sjögren syndrome and systemic lupus erythematosus. Autoantibodies to SSB are found in the serum of patients with these diseases, and are used as a diagnostic marker.
See also
References
External links
- Sjögren syndrome antigen B at WikiMD
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