Sirtuin 1

Sirtuin 1 (also known as SIRT1) is a protein that in humans is encoded by the SIRT1 gene. It is a member of the sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT1 is known to regulate important biological pathways in bacteria, archaea, and eukaryotes.

Function

SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity). The complex formed by SIRT1 and its cofactor NAD+ (nicotinamide adenine dinucleotide) catalyzes the deacetylation of many important biological molecules.

Role in Disease and Aging

SIRT1 has been implicated in a variety of diseases, including cancer, diabetes, and neurodegenerative diseases. It has also been suggested to play a role in the aging process, with studies showing that increased SIRT1 activity can extend the lifespan of yeast, worms, and flies.

Research

Research into SIRT1 has been extensive, with studies investigating its role in disease and aging, as well as its potential as a therapeutic target.

See Also

• Sirtuin
• Protein
• Gene
• Enzyme
• NAD+
• Cancer
• Diabetes
• Neurodegenerative diseases