Semapimod
Semapimod
Semapimod (pronunciation: /sɛməˈpɪmod/) is a synthetic molecule with potential anti-inflammatory and immunomodulatory activities.
Etymology
The term "Semapimod" is derived from the combination of the words "semi", meaning half, and "pimod", a non-specific term often used in the naming of synthetic molecules.
Definition
Semapimod is a synthetic guanylhydrazone that inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-12 (IL-12), and interferon gamma (IFN-gamma) by macrophages. It is primarily used in the treatment of rheumatoid arthritis and Crohn's disease.
Mechanism of Action
Semapimod works by inhibiting the activation of macrophages and monocytes, which are key cells involved in the body's immune response. By doing so, it reduces the production of pro-inflammatory cytokines, which are proteins that promote inflammation.
Related Terms
- Cytokines: Proteins that are produced by cells of the immune system. They are involved in cell signaling and can stimulate the movement of cells towards sites of inflammation, infection, and trauma.
- Guanylhydrazones: A class of synthetic compounds that have been studied for their potential anti-inflammatory and immunomodulatory activities.
- Immunomodulators: Substances (drugs and nutrients) that influence the functions of the immune system.
- Inflammation: A process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses.
External links
- Medical encyclopedia article on Semapimod
- Wikipedia's article - Semapimod
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