Schmidt

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Schmidt Syndrome

Schmidt Syndrome (pronounced: sh-mit sin-drome), also known as Polyglandular Autoimmune Syndrome Type II or PGA Type II, is a rare autoimmune disorder characterized by the occurrence of Addison's disease in combination with autoimmune thyroid disease and/or type 1 diabetes mellitus.

Etymology

The syndrome is named after German endocrinologist Martin Benno Schmidt who first described the condition in 1926.

Definition

Schmidt Syndrome is a form of polyglandular autoimmune syndrome (PGA), a group of autoimmune disorders that affect multiple endocrine glands. In the case of Schmidt Syndrome, the affected glands are usually the adrenal, thyroid, and pancreas.

Symptoms

The symptoms of Schmidt Syndrome can vary greatly depending on the glands affected. Common symptoms include fatigue, weight loss, low blood pressure, skin changes, and in severe cases, adrenal crisis. If the thyroid is affected, symptoms may include weight gain, fatigue, and depression. If diabetes is present, symptoms may include frequent urination, excessive thirst, and unexplained weight loss.

Diagnosis

Diagnosis of Schmidt Syndrome is based on clinical symptoms and laboratory tests that confirm the presence of autoimmune diseases affecting the endocrine glands. These tests may include blood tests, imaging tests, and in some cases, biopsy of the affected gland.

Treatment

Treatment for Schmidt Syndrome focuses on managing the symptoms and replacing the hormones that the affected glands are unable to produce. This may include hormone replacement therapy, medication to manage symptoms, and lifestyle changes to manage the condition.

Related Terms

External links

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